GSM4336571[Accession] - GEO DataSets

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Items: 4

Select item 2001458301.

Ileal single-cell analysis in the context of inflammation focused on tuft cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL19057 GPL19415
26 Samples

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Accession:: GSE145830

ID:: 200145830

PubMed Full text in PMC Similar studies

Select item 2001458272.

WT/AtohKO/TNFdARE Ileum

(Submitter supplied) An inverse correlation between countries endemic for helminth infestation and Crohn's disease (CD) incidences has been reinforced by anecdotal but successful cases of helminth therapy for CD. Recent studies have revealed that tuft cells in the small intestine are critical for sensing helminths and directing a type 2 immune response to counteract colonization. Here, we establish an inverse relationship between chemosensory tuft cells and local tissue inflammation in CD patients as well as an established mouse model of TNF-á-induced Crohn's-like ileitis (TNFÄARE). more...