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Items: 3

1.

Targeting HDAC6-Mediated Deacetylation of STAT4 Is Critical for T helper Type 1 Cell Differentiation and Capability

(Submitter supplied) We report that inhibition and knockout of HDAC6 enhanced Th1 cell differentiation, and decreased Listeria monocytogenes infection in mice. Mechanistically, HDAC6 directly deacetylated CBP-catalyzed acetylation on STAT4 lysine 667 via its enzymatic activity, which is required for IL-12-induced phosphorylation on STAT4. Stat4K667R mutant mice lost the ability to normally differentiate Th1 cell and developed sever L. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
18 Samples
Download data: TXT
Series
Accession:
GSE146253
ID:
200146253

SRA Run Selector

2.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11036 Series
298039 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

3.

CD4+ T cells, WT-Th0_3

Organism:
Mus musculus
Source name:
CD4+ T cells
Platform:
GPL17021
Series:
GSE146253
Download data
Sample
Accession:
GSM4368960
ID:
304368960

SRA Run Selector

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db=gds|term=GSM4368960[Accession]|query=1|qty=2|blobid=MCID_6705bc10c150633680299014|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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