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Items: 3

1.

Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic "integrated stress response"

(Submitter supplied) Various stress conditions are signaled through phosphorylation of translation initiation factor eukaryotic initiation factor 2α (eIF2α) to inhibit global translation while selectively activating transcription factor ATF4 to aid cell survival and recovery. However, this integrated stress response is acute and cannot resolve lasting stress. Here, we report that tyrosyl-tRNA synthetase (TyrRS), a member of the aminoacyl-tRNA synthetase family that responds to diverse stress conditions through cytosol-nucleus translocation to activate stress-response genes, also inhibits global translation. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: XLSX
Series
Accession:
GSE155309
ID:
200155309
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

TyrRS rep1 input

Organism:
Homo sapiens
Source name:
HEK293
Platform:
GPL11154
Series:
GSE155309
Download data
Sample
Accession:
GSM4698819
ID:
304698819
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