GSM471092[Accession] - GEO DataSets

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Items: 3

Select item 2000190341.

EYA4 is a non-small cell lung cancer tumor suppressor located in the susceptibility locus on chromosome 6q

(Submitter supplied) This study was undertaken to identify novel tumour suppressor genes in lung adenocarcinoma. EYA4, located at 6q23.2 was identified as a frequently lost and hypermethylated gene in the analyzed samples. EYA4 is underexpressed in addition to being deleted and hypermethylated. Control of EYA4 expression by DNA methylation was assessed using 5'-azacytidine. The role of EYA4 in apoptosis was assessed using a stable knock down of the gene which was assessed for apoptotis using FACS and qPCR.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL8490 GPL2616
90 Samples

Download data: IDAT, TXT

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Accession:: GSE19034

ID:: 200019034

Analyze with GEO2R

Select item 1000084902.

Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)

(Submitter supplied) HumanMethylation27 DNA Analysis BeadChip allows researchers to interrogate 27,578 highly informative CpG sites per sample at single-nucleotide resolution. This 12-sample BeadChip features content derived from the well-annotated NCBI CCDS database (Genome Build 36) and is supplemented with more than 1,000 cancer-related genes described in published literature. Probe content has been enriched to deeply cover more than 150 well-established cancer genes known to show differential methylation patterns. more...