GSM4728065[Accession] - GEO DataSets

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Items: 4

Select item 2001562731.

Core transcription regulatory circuitry orchestrates stratified epithelial homeostasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
44 Samples

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Series

Accession:: GSE156273

ID:: 200156273

PubMed Full text in PMC Similar studies

Select item 2001562722.

Core transcription regulatory circuitry orchestrates stratified epithelial homeostasis (ChIP-seq, ATAC-seq)

(Submitter supplied) Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and transcriptional regulatory networks. Here, by integrating super-enhancer and chromatin accessibility landscapes, we delineate core transcription regulatory circuitries (CRCs) of limbal stem/progenitor cells (LSCs) and find that RUNX1 and SMAD3 are required for maintenance of the corneal epithelial identity and homeostasis. more...