GSM4798168[Accession] - GEO DataSets

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Items: 4

Select item 2001583441.

De novo DNA methylation suppresses aberrant fate trajectory during epiblast transition [ATAC-seq]

(Submitter supplied) Genome remethylation is essential for mammalian development. Here we examined cell fate in the absence of de novo DNA methyltransferases. We found that embryonic stem (ES) cells deficient for Dnmt3a and Dnmt3b are rapidly eliminated from chimaeras. Pluripotency progression is derailed towards extra-embryonic trophoblast. This aberrant trajectory is propelled by failure to methylate and suppress expression of Ascl2 during formative transition. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
14 Samples

Download data: BW

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Accession:: GSE158344

ID:: 200158344

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001583472.

Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory

(Submitter supplied) Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient for both Dnmt3a and Dnmt3b are rapidly eliminated from chimeras. On further investigation we found that in vivo and in vitro the formative pluripotency transition is derailed toward production of trophoblast. more...