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Items: 4

1.

­De novo DNA methylation suppresses aberrant fate trajectory during epiblast transition [ATAC-seq]

(Submitter supplied) Genome remethylation is essential for mammalian development. Here we examined cell fate in the absence of de novo DNA methyltransferases. We found that embryonic stem (ES) cells deficient for Dnmt3a and Dnmt3b are rapidly eliminated from chimaeras. Pluripotency progression is derailed towards extra-embryonic trophoblast. This aberrant trajectory is propelled by failure to methylate and suppress expression of Ascl2 during formative transition. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
14 Samples
Download data: BW
Series
Accession:
GSE158344
ID:
200158344
2.

Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory

(Submitter supplied) Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient for both Dnmt3a and Dnmt3b are rapidly eliminated from chimeras. On further investigation we found that in vivo and in vitro the formative pluripotency transition is derailed toward production of trophoblast. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
18 Samples
Download data: BW
Series
Accession:
GSE158347
ID:
200158347
3.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
4.

18/5 DKO GFP HIGH 2

Organism:
Mus musculus
Source name:
mEpiLC
Platform:
GPL13112
Series:
GSE158344 GSE158347
Download data: BW
Sample
Accession:
GSM4798178
ID:
304798178
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Supplemental Content

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