GSM4873682[Accession] - GEO DataSets

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Items: 4

Select item 2001604701.

Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
134 Samples

Download data: BROADPEAK, BW, NARROWPEAK

Series

Accession:: GSE160470

ID:: 200160470

Select item 2001604582.

Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [RNA-seq]

(Submitter supplied) Genetic models suggested that SMARCA5 was required for DNA templated events including transcription, DNA replication and DNA repair. We engineered a degron tag into the endogenous alleles of SMARCA5, a catalytic component of the imitation switch (ISWI) complexes, in three different human cell lines to define the effects of rapid degradation of this key regulator. Degradation of SMARCA5 was associated with a rapid increase in global nucleosome repeat length, which may allow greater chromatin compaction. more...