GSM4915181[Accession] - GEO DataSets

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Items: 4

Select item 2001618221.

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL24973 GPL24247
111 Samples

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Series

Accession:: GSE161822

ID:: 200161822

PubMed Similar studies

Select item 2001618192.

DNA replication timing directly regulates the frequency of oncogenic chromosomal translocations [Repli-seq]

(Submitter supplied) Many cancers originate from misregulation of gene expression caused by chromosomal translocations which result from ligation of DNA double-strand breaks (DSBs). Indeed, translocations may be causal in ~20% of human cancer morbidity 1. Although the sources of DSBs are numerous2-5, we have virtually no knowledge of the steps linking DSB formation to DSB ligation. Here, we show that early replication timing of translocation partner loci, mediated by the activity of replication origins, is a critical regulator of lymphomagenic Myc translocations generated by activation-induced deaminase (AID) during antibody maturation in B-cells. more...