GSM5049011[Accession] - GEO DataSets - NCBI

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Items: 3

Select item 2001657321.

Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection

(Submitter supplied) Viral infection both activates stress signaling pathways and redistributes ribosomes away from host mRNAs to translate viral mRNAs. The intricacies of this ribosome shuffle from host to viral mRNAs are poorly understood Here, we uncover a role for the ribosome associated quality control (RQC) factor, ZNF598, during vaccinia virus mRNA translation. ZNF598 acts on collided ribosomes to ubiquitylate 40S subunit proteins uS10 and eS10 initiating RQC-dependent nascent chain degradation and ribosome recycling We show that vaccinia infection in human cells enhances uS10 ubiquitylation indicating an increased burden on RQC pathways during viral propagation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
18 Samples

Download data: TXT

Series

Accession:: GSE165732

ID:: 200165732

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000111542.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10565 Series
183879 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3050490113.

HCT116-uS10-KI (RPS20-KI)-8hpi-VACV-WR-replicate 1 [RPS20_KI_8hpi_1]

Organism:: Homo sapiens

Source name:: HCT116-uS10-KI (RPS20-KI)-8hpi-VACV-WR

Platform:: GPL11154
Series:: GSE165732

Sample

Accession:: GSM5049011

ID:: 305049011

SRA Run Selector

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GSM5049011[Accession] (3)
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