GSM5556473[Accession] - GEO DataSets

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Items: 4

Select item 2001895701.

HMGA1 Chromatin Regulators Drive MPN Progression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791 GPL24247
25 Samples

Download data: H5, TXT

Series

Accession:: GSE189570

ID:: 200189570

PubMed Full text in PMC Similar studies

Select item 2001833742.

HMGA1 Chromatin Regulators Drive MPN Progression [RNA-Seq]

(Submitter supplied) Myeloproliferative neoplasms (MPN) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although actionable mechanisms driving progression remain elusive. The HMGA1 chromatin regulator is up-regulated during MPN progression with highest levels after transformation. HMGA1 depletion in JAK2V617F MPN AML cell lines disrupts proliferation, clonogenicity, and leukemic engraftment. more...