GSM5884399[Accession] - GEO DataSets

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Items: 4

Select item 2001964501.

Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL30173 GPL20795
126 Samples

Download data: BED, BW, HIC, TXT

Series

Accession:: GSE196450

ID:: 200196450

PubMed Full text in PMC Similar studies

Select item 2001964492.

Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors [RNA-seq]

(Submitter supplied) Cohesin plays vital roles in chromatin folding and gene expression regulation, cooperating with such factors as cohesin loaders, unloaders, and the insulation factor CTCF. Although models of regulation have been proposed (e.g., loop extrusion), how cohesin and related factors collectively or individually regulate the hierarchical chromatin structure and gene expression remains unclear. We have depleted cohesin and related factors and then conducted a comprehensive evaluation of the resulting 3D genome, transcriptome and epigenome data. more...