GSM6226314[Accession] - GEO DataSets

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Items: 4

Select item 2002057831.

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL21103
170 Samples

Download data: BEDGRAPH, BIGWIG, COOL, NARROWPEAK, TXT

Series

Accession:: GSE205783

ID:: 200205783

PubMed Full text in PMC Similar studies

Select item 2002057812.

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos [RNA-seq]

(Submitter supplied) During development, Hox genes are activated in a time sequence following their relative positions on their clusters, leading to the proper identities of structures along the rostral to caudal axis. To understand the mechanism operating this Hox timer, we used ES-cells derived stembryos and show that the core of the process involves the start of transcription at the anterior part of the cluster, following Wnt signaling, and a concomitant loading of cohesin complexes enriched on the transcribed DNA segments, i.e., with an asymmetric distribution in favor of the anterior part the gene cluster. more...