GSM643910[Accession] - GEO DataSets

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Items: 5

Select item 2000320171.

Molecular profiling of human mammary gland links breast cancer risk to a p27+ cell population with progenitor characteristics

(Submitter supplied) Gene expression, DNA and histone methylation profiles were performed on multiple cell types purified from normal human nulliparous and parous breast tissue using SAGE-seq, MSDK-seq and ChIP-seq [GSE26141].

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL9052
42 Samples

Download data: TXT

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Accession:: GSE32017

ID:: 200032017

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000261412.

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL9052
41 Samples

Download data: TXT

Series

Accession:: GSE26141

ID:: 200026141

PubMed Full text in PMC Similar studies

Select item 2000261393.

Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [MSDK-Seq]

(Submitter supplied) Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylation (H3K27me3) enrichment and DNA methylation of genes expressed in a cell type-specific manner, suggesting their regulation by epigenetic mechanisms and a dynamic interplay between the two processes that together define developmental potential. more...