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Items: 3

1.

Gene regulatory loops at lamina-associated domains

(Submitter supplied) The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are repressed, approximately ten percent reside in local euchromatic contexts and are expressed. How these genes are regulated and whether they are able to contact regulatory elements in LADs or outside LADs remains unclear. Here, we integrate transcriptomic, chromatin states, microscopy and publicly available enhancer-capture Hi-C data to show that expressed genes in LADs are able to connect to enhancers in LADs and inter-LADs. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL20301 GPL18573 GPL24676
13 Samples
Download data: BED, BEDGRAPH, BROADPEAK, BW, NARROWPEAK
Series
Accession:
GSE221288
ID:
200221288
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

ChIPseq_PROLIF_G_H3K27ac

Organism:
Homo sapiens
Source name:
Adipose (gluteofemoral)
Platform:
GPL18573
Series:
GSE221288
Download data: BW, NARROWPEAK
Sample
Accession:
GSM6857891
ID:
306857891
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Supplemental Content

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