GSM701368[Accession] - GEO DataSets

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Items: 4

Select item 2000283671.

Expression and SNP data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL5175 GPL8882
26 Samples

Download data: CEL

Series

Accession:: GSE28367

ID:: 200028367

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000283652.

Expression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative

(Submitter supplied) A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplication of SNCA encoding α-synuclein. α-Synuclein dysfunction is common to all forms of PD, and SNCA triplication leads to fully penetrant familial PD with accelerated pathogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
15 Samples

Download data: CEL

Series

Accession:: GSE28365

ID:: 200028365

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000051753.

[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 Oct 11, 2012: annotation table updated with netaffx build 32 Protocol: See manufacturer's web site