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Items: 4

1.

RIF1 regulates early replication timing in murine B cells.

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating murine B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin and promotes early replication, but plays a minor role in regulating replication origin activity, gene expression and genome organization in B cells. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
69 Samples
Download data: BEDGRAPH, BW, HIC, MCOOL
Series
Accession:
GSE228880
ID:
200228880
2.

RIF1 regulates replication origin activity and early replication timing in B cells [Repli-Seq]

(Submitter supplied) The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermutating B lymphocytes, RIF1 binds predominantly to early-replicating active chromatin, regulates early origin firing and promotes early replication. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL30172
36 Samples
Download data: BED, BEDGRAPH, BW
Series
Accession:
GSE228878
ID:
200228878
3.

NextSeq 2000 (Mus musculus)

Platform
Accession:
GPL30172
ID:
100030172
4.

priB_Repliseq_Rif1KO_Het_early_rep3

Organism:
Mus musculus
Source name:
priB
Platform:
GPL30172
Series:
GSE228878 GSE228880
Download data
Sample
Accession:
GSM7141018
ID:
307141018
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Supplemental Content

db=gds|term=GSM7141018[Accession]|query=1|qty=2|blobid=MCID_665221b3d01e38019cd8e790|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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