GEO DataSets

(Submitter supplied) Transfer RNAs (tRNAs) are one of the most conserved components of protein synthesis machinery. An effective strategy for microbes to defend against viruses or competitors is to employ anticodon nucleases (ACNases) to deplete essential tRNAs and thereby shut off global protein synthesis, but this strategy has not been observed in multicellular eukaryotes. Here, we report that human SAMD9 is a virus-activatable ACNase that specifically depletes phenylalanine tRNA (tRNAPhe), causing codon-specific ribosomal pausing and inducing stress signaling. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platform:

GPL18573

12 Samples

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