GSM7316515[Accession] - GEO DataSets

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Items: 4

Select item 2002321521.

Massively parallel saturation genome editing of an essential mitochondrial targeting sequence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
57 Samples

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Series

Accession:: GSE232152

ID:: 200232152

Select item 2002321512.

Massively parallel saturation genome editing of an essential mitochondrial targeting sequence (Tn5)

(Submitter supplied) We employed saturation genome editing (SGE) to assess the functional consequences of synonymous, missense, and nonsense variants across KARS1 exon 2. Deep DNA sequencing of fixed-amplicon PCR products targeting the endogenous KARS1 Exon 2 locus was used to determine variant frequencies as part of a larger study to identify a set of reproducible enrichment scores indicating effects of variants on KARS1 function.