GSM7385430[Accession] - GEO DataSets

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Items: 4

Select item 2002328871.

A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL11154 GPL21103
17 Samples

Download data: BED, BW, COOL, HIC, NARROWPEAK

Series

Accession:: GSE232887

ID:: 200232887

PubMed

Select item 2002328812.

A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival [C-HiC]

(Submitter supplied) Gene deserts spanning more than 500kb of non-protein coding genomic sequence are considered evolutionarily ancient and stable and are enriched in the vicinity of developmental regulator genes (Ovcharenko 2005). These extensive genomic regions typically harbor numerous conserved elements with predicted gene regulatory potential pointing to critical tissue-specific functions during development. Nevertheless, the biological necessity and underlying funtional enhancer landscapes of most gene deserts near developmental transcription factors (TFs) remain unknown, and it is unclear how precise pleiotropic expression patterns emerge from gene desert sequence. more...