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Items: 3

1.

Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DRlow/neg monocytes in lower-risk myelodysplastic neoplasms

(Submitter supplied) Recurrent mutations in splicing factors, in particular the splicing factor 3B subunit 1 (SF3B1), are commonly seen in lower-risk (LR) myelodysplastic neoplasms (MDS) and result in various aberrantly spliced transcripts. The cell type-specific changes and their contribution to immune dysregulation in MDS remain vaguely understood. In this study, we performed RNA sequencing on classical monocytes isolated from patients with an isolated SF3B1K700E hotspot mutation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
9 Samples
Download data: CSV
Series
Accession:
GSE236535
ID:
200236535
2.

Illumina HiSeq 4000 (Homo sapiens)

Platform
Accession:
GPL20301
ID:
100020301
3.

PB_classical monocytes,SF3B1K700E LR-MDS, patient 3

Organism:
Homo sapiens
Source name:
PBMCs
Platform:
GPL20301
Series:
GSE236535
Download data
Sample
Accession:
GSM7549616
ID:
307549616
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