GSM7655062[Accession] - GEO DataSets

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Items: 4

Select item 2002378301.

Flexible and scalable control of T cell memory by a reversible epigenetic switch

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247
24 Samples

Download data: BW, H5, MTX, TSV, TXT

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Accession:: GSE237830

ID:: 200237830

Select item 2002378282.

Flexible and scalable control of T cell memory by a reversible epigenetic switch (RNA-seq)

(Submitter supplied) In this study, we find that the Tcf7+ CD8 T cells present following acute challenge can form either from cells that maintain Tcf7 expression throughout activation or from cells that silence Tcf7 and reactivate it after stimulation removal. In this experiment, we asked whether both pathways can give rise to cells with genomic characteristics of memory. To do this, we activated naive CD8 T cells ex vivo for 2 days followed by 1 day of culture without TCR stimulation. more...