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Items: 4

1.

Estrogen-dependent gene expression in human breast cancer cells relies upon proteosome-dependent monoubiquitination of histone H2B

(Submitter supplied) The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate estrogen-induced transcription but the mechanisms by which it influences ERα function remain controversial. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4090
Platform:
GPL14010
21 Samples
Download data: CEL
Series
Accession:
GSE31118
ID:
200031118
2.
Full record GDS4090

Proteasome inhibitor Bortezomib or proteasome subunit knockdown effect on MCF7 breast cancer cells

Analysis of MCF7 cells stimulated with bortezomib or depleted of PSMB3 or PSMB5. Proteasome inhibition can regulate estrogen-induced transcription. Results provide insight into mechanisms by which proteasome inhibition influences ERα function and into improved strategies for breast cancer treatment
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 agent, 5 genotype/variation, 2 protocol sets
Platform:
GPL14010
Series:
GSE31118
21 Samples
Download data: CEL
DataSet
Accession:
GDS4090
ID:
4090
3.

[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [hugene10stv1hsentrezg]

(Submitter supplied) Probe set data extracted from custom CDF (hugene10stv1hsentrezg.cdf) Protocol: See manufacturer's web site
Organism:
Homo sapiens
1 DataSet
1 Series
1 Related Platform
21 Samples
Download data: CDF
Platform
Accession:
GPL14010
ID:
100014010
4.

siRNA_PSMB5A

Organism:
Homo sapiens
Source name:
aneuploid, breast adenocarcinoma cell line
Platform:
GPL14010
Series:
GSE31118
Dataset:
GDS4090
Download data: CEL
Sample
Accession:
GSM770589
ID:
300770589
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Supplemental Content

db=gds|term=GSM770589[Accession]|query=1|qty=2|blobid=MCID_666ddeec909a3d46adb001a6|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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