GSM7874600[Accession] - GEO DataSets

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Items: 4

Select item 2002468071.

TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247
10 Samples

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Series

Accession:: GSE246807

ID:: 200246807

PubMed Full text in PMC Similar studies

Select item 2002466852.

TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway [RNA-Seq]

(Submitter supplied) Cranial neural crest development is governed by positional gene regulatory networks (GRNs). Fine-tuning of the GRN components underly facial shape variation, yet how those in the midface are connected and activated remain poorly understood. Here, we show that concerted inactivation of Tfap2a and Tfap2b in the murine neural crest, even during the late migratory phase, results in a midfacial cleft and skeletal abnormalities. more...