GSM7903961[Accession] - GEO DataSets

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Items: 4

Select item 2002479701.

Cell of origin epigenetic priming determines susceptibility to Tet2 oncogenic mutation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21626 GPL24247
76 Samples

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Series

Accession:: GSE247970

ID:: 200247970

PubMed Full text in PMC Similar studies

Select item 2002479692.

Cell of origin epigenetic priming determines susceptibility to Tet2 oncogenic mutation [bulk ATAC-seq]

(Submitter supplied) Hematopoietic stem cell mutations can result in clonal hematopoiesis (CHIP) but the clinical outcomes are heterogeneous. The nature of the founder mutation and secondary mutations likely drive emergent neoplastic disease. We investigated how the cell state where the TET2 mutation occurs affects susceptibility to that commonly occurring CH mutation. Here, we provide evidence that risk is written in the epigenome of the cell of origin. more...