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Items: 3

1.

Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration.

(Submitter supplied) Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) transcriptional coactivators are key regulators of energy metabolism-related genes and are expressed in energy-demanding tissues. There are several PGC-1α variants with different biological functions in different tissues. The brain is one of the tissues where the role of PGC-1α isoforms remains less explored. Here, we used a toxin-based mouse model of Parkinson's disease (PD) and observed that the expression levels of variants PGC-1α2 and PGC-1α3 in the nigrostriatal pathway increases at the onset of dopaminergic cell degeneration. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
15 Samples
Download data: TXT
Series
Accession:
GSE248504
ID:
200248504

2.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11033 Series
297701 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

3.

Astrocytes, PGC-1a2 adenovirus infected, rep1

Organism:
Mus musculus
Source name:
mouse primary astrocyte cells
Platform:
GPL17021
Series:
GSE248504
Download data
Sample
Accession:
GSM7916077
ID:
307916077

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db=gds|term=GSM7916077[Accession]|query=1|qty=2|blobid=MCID_67028bdfd3e79154ac5cbcc5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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