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Items: 4

1.

Therapeutic application of circular RNA aptamers in a mouse model of psoriasis

(Submitter supplied) Efforts to advance RNA aptamers as a novel therapeutic modality have been limited by their susceptibilty to degradation and immunogenicity. In a previous study, we demonstrated synthesized double-stranded circular RNAs (ds-cRNAs) with minimal immunogenicity targeted to dsRNA-activated Protein Kinase R (PKR). Here, we test the therapeutic potential of ds-cRNAs in a mouse model of imiquimod-induced psoriasis. more...
Organism:
synthetic construct; Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL26526 GPL24247
40 Samples
Download data: TXT, XLS
Series
Accession:
GSE248680
ID:
200248680
2.

circSHAPE-MaP of EPIC

(Submitter supplied) Efforts to advance RNA aptamers as a novel therapeutic modality have been limited by their susceptibilty to degradation and immunogenicity. In a previous study, we demonstrated synthesized double-stranded circular RNAs (ds-cRNAs) with minimal immunogenicity targeted to dsRNA-activated Protein Kinase R (PKR). Here, we test the therapeutic potential of ds-cRNAs in a mouse model of imiquimod-induced psoriasis. more...
Organism:
synthetic construct
Type:
Other
Platform:
GPL26526
22 Samples
Download data: TXT
Series
Accession:
GSE248679
ID:
200248679
3.

Illumina NovaSeq 6000 (synthetic construct)

Organism:
synthetic construct
84 Series
484 Samples
Download data
Platform
Accession:
GPL26526
ID:
100026526
4.

EPIC-2 NAI,repeat1

Organism:
synthetic construct
Source name:
N/A
Platform:
GPL26526
Series:
GSE248679 GSE248680
Download data: TXT
Sample
Accession:
GSM7918662
ID:
307918662
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Supplemental Content

db=gds|term=GSM7918662[Accession]|query=1|qty=3|blobid=MCID_66997e0b57bd0c11903778d5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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