GSM7973488[Accession] - GEO DataSets

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Items: 4

Select item 2002500691.

Biphasic Regulation of Epigenetic State by Matrix Stiffness during Cell Reprogramming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

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Series

Accession:: GSE250069

ID:: 200250069

PubMed Full text in PMC Similar studies

Select item 2002500682.

Biphasic Regulation of Epigenetic State by Matrix Stiffness during Cell Reprogramming [RNA-seq]

(Submitter supplied) In this study, we investigate how matrix stiffness regulates chromatin reorganization and cell reprogramming, and find that matrix stiffness acts as a biphasic regulator of epigenetic state and fibroblast-to-neuron conversion efficiency, maximized at an intermediate stiffness of 20 kPa. ATAC-sequencing analysis shows the same trend of chromatin accessibility to neuronal genes at these stiffness levels. more...