GSM7995359[Accession] - GEO DataSets

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Items: 4

Select item 2002521631.

Large-scale discovery of potent, compact and lineage specific enhancers for gene therapy vectors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL20301 GPL18573 GPL24676
29 Samples

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Accession:: GSE252163

ID:: 200252163

Select item 2002521612.

Large-scale discovery of potent, compact and lineage specific enhancers for gene therapy vectors [RNA-seq]

(Submitter supplied) Regulation of gene expression during cell development and differentiation is chiefly orchestrated by distal noncoding regulatory elements that precisely modulate cell selective gene activity. Gene therapy vectors rely on the cellular and context specificity of regulatory DNA elements to express therapeutic transgenes in the correct location and time. Here, we develop a straight-forward, one-shot approach to screen putative regulatory sequences identified in large-scale epigenomics profiling experiments for precise and programmable control of transgenes encoded within gene therapy viral vectors. more...