GSM818964[Accession] - GEO DataSets

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Items: 4

Select item 2000330631.

Process-sensitive sentinel genes as novel cell culture comparability metrics

(Submitter supplied) Biotechnology-derived therapeutics manufacturing is highly regulated to assure product quality, safety and efficacy. Process conditions are closely monitored as they can influence product characteristics. Culture of mammalian cells at different scales is a vital part of biomanufacturing. Currently, scale up of bioreactors is largely done based on engineering parameters such as oxygen transfer and mixing characteristics. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14743
23 Samples

Download data: GPR

Series

Accession:: GSE33063

ID:: 200033063

Select item 2000330622.

Genomic analysis for predicting cell culture status in a sparged bench-scale 5L bioreactor

(Submitter supplied) There is a great need for setting novel measurable attributes at the cell physiological level in a scalable biopharmaceutical production process to be able to predict the process outcomes and improve process understanding. In a biologic production process, changes in culture environment due to several factors such as shear and bubble induced damage from gas sparging and agitation are known to occur. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14743
10 Samples

Download data: GPR

Series

Accession:: GSE33062

ID:: 200033062

Select item 1000147433.

Mm-FDA-OperonV4-35K

(Submitter supplied) The mouse genome oligonucleotide probe set version 4.0 contains 35,852 optimized 70mers (plus controls) obtained from Operon (no more existing). The oligonucleotide probes were purchased in 384-well polypropylene plates (Genetix, 384 micro array) and dissolved in a print buffer (150mM sodium phosphate, pH 8.5, 4% sodium sulfate) at a concentration of 15 uM. The microarray is composed of 48 blocks and one spot is printed per probe per slide. more...