U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 2226989

1.

Faecalibacterium prausnitzii-derived extracellular vesicles alleviate chronic colitis-related intestinal fibrosis by macrophage metabolic reprogramming II

(Submitter supplied) Faecalibacterium prausnitzii (F. prausnitzii) has been recognized for its various intestinal and extraintestinal benefits to human. And reduction of F. prausnitzii has been linked to an increased risk of intestinal fibrosis in patients of Crohn’s disease (CD). In this study, oral administration of either live F. prausnitzii or its extracellular vesicles (FEVs) can markedly mitigate the severity of fibrosis in mice induced by repetitive administration of DSS. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: XLS
Series
Accession:
GSE267482
ID:
200267482
2.

The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development

(Submitter supplied) The glycosylphosphatidylinositol (GPI) biosynthetic pathway in the endoplasmic reticulum (ER) is crucial for generating GPI-anchored proteins (GPI-APs), which are translocated to the cell surface and play a vital role in cell signaling and adhesion. This study focuses on two integral components of the GPI pathway, the PIGL and PIGF proteins, and their significance in trophoblast biology. We show that GPI pathway mutations impact on placental development impairing the development of the syncytiotrophoblast (SynT), and especially the SynT-II layer, which is essential for the establishment of the definitive nutrient exchange area within the placental labyrinth. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
45 Samples
Download data: XLSX
Series
Accession:
GSE266153
ID:
200266153
3.

The role of CD4 T cells in tumor-specific CD8 T cell reprogramming [ATAC-Seq]

(Submitter supplied) ATAC-seq analysis of tumor-specific CD8 T cells from tumors with and without tumor-specific CD4 T cells
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: BW, CSV, NARROWPEAK
Series
Accession:
GSE265847
ID:
200265847
4.

The role of CD4 T cells in tumor-specific CD8 T cell reprogramming [RNA-Seq]

(Submitter supplied) RNA-seq analysis of tumor-specific CD8 T cells from tumors with and without tumor-specific CD4 T cells
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: COUNTS
Series
Accession:
GSE265846
ID:
200265846
5.

Acetylation is not mere a consequence of transcription: histones are acetylated without ongoing transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL19057 GPL30172
8 Samples
Download data
Series
Accession:
GSE260969
ID:
200260969
6.

Tumor macrophages treated with exosomes

(Submitter supplied) Macrophages treated with exosomes containing high levels of MEK1 express chemokines
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: TXT
Series
Accession:
GSE203577
ID:
200203577
7.

Tumor macrophages from rejecting and growing tumors

(Submitter supplied) Macrophages in rejecting tumors have IFNg gene signature
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
5 Samples
Download data: TXT
Series
Accession:
GSE203576
ID:
200203576
8.

Single-cell Total-RNA Profiling Unveils Regulatory Hubs of Transcription Factors

(Submitter supplied) Recent development of RNA velocity uses master equations to establish the kinetics of the life cycle of RNAs from unspliced RNA to spliced RNA (i.e., mature RNA) to degradation. To feed this kinetic analysis, simultaneous measurement of unspliced RNA and spliced RNA in single cells is greatly desired. However, the majority of single-cell RNA-seq chemistry only captures mature RNA species to measure gene expressions. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL19057
1089 Samples
Download data: TXT
Series
Accession:
GSE202126
ID:
200202126
9.

snRNA-seq of white and brown adipose tisssue from adipocyte-specific Gls knockout mouse

(Submitter supplied) We generated single nucleus transcriptomic atlas for white and brown adipose tissue from adipocyte-specific Gls knockout mouse
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30172
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE267800
ID:
200267800
10.

Transthyretin orchestrates vitamin B12-induced stress resilience [II]

(Submitter supplied) Background: Chronic stress significantly contributes to mood- and anxiety disorders. Previous data suggest a correlative connection between vitamin B12 supplementation, depression, and stress resilience. However, the underlying mechanisms are still poorly understood. Methods: Using the chronic variable stress mouse model coupled with RNA-sequencing, we determined vitamin B12-induced transcriptional changes related to stress resilience. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
16 Samples
Download data: TSV
Series
Accession:
GSE267339
ID:
200267339
11.

RNA sequencing of NPM1cA/SMC+/- mouse myeloid sarcoma and whole bone marrow

(Submitter supplied) This study was designed to investigate the RNA sequencing profile of mouse myeloid sarcomas in comparison to their matched whole bone marrow acute myeloid leukemia specimens. The goal was to determine gene set profiles that are different between the two phenotypes in the same primary genetic driver of AML mutation in mice to further investigate the results demonstrated in the patient derived specimens.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
16 Samples
Download data: CSV, XLSX
Series
Accession:
GSE264700
ID:
200264700
12.

Single-cell gene expression profile of intra-islet immune cell populations in WT NOD and NOD.Cxcl16-/- mice

(Submitter supplied) We examined how Cxcl16 deficiency may alter autoimmune responses targeting pancreatic islets, with a focus on changes in islet-infiltrating CD4 and CD8 T cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE262101
ID:
200262101
13.

Ubiquitination of hepatic APOC3 by GM47544 prevents hypertriglyceridemia and ameliorates atherosclerosis

(Submitter supplied) To investigate the function of lnc GM47544 in the regulation of triglyceride, we established AML-12 cell lines in which lnc GM47544 has been stably overexpressed by lentivirus. We then performed gene expression profiling analysis using data obtained from RNA-seq of AML-12-pLKO.1 (control) and AML-12-GM47544 (O/E).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: TXT
Series
Accession:
GSE232866
ID:
200232866
14.

Transcriptomic Landscape of Hras12V Oncogene-Induced Hepatocarcinogenesis with Gender Disparity

(Submitter supplied) The genesis of hepatocellular carcinoma (HCC) is closely related to hyper-activated Ras signals and male factors. This study aimed to characterize the underlying mechanisms by examining the transcriptome of Hras12V transgenic mice (Ras-Tg, HCC model). A transcriptomic database was established via RNA-Seq of HCC (T) and the adjacent precancerous liver tissue (P) of Ras-Tg and the normal liver tissue of wild-type mice (W) of both sexes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE232694
ID:
200232694
15.

Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers, single-cell RNA-seq

(Submitter supplied) Glutamine metabolism in the tumor microenvironment is emerging as a critical regulator of immune-mediated anti-tumor responses. We report potent tumor growth inhibition by the glutamine antagonist prodrug JHU083 in urologic tumors by JHU083-reprogrammed tumor-associated macrophages (TAMs) and tumor-infiltrating monocytes (TIMs). Using orthogonal approaches, we show that JHU083-mediated glutamine antagonism in the tumor microenvironment induces TNF, inflammatory, and mTORC1 signaling in different intra-tumoral TAM clusters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: H5
Series
Accession:
GSE229223
ID:
200229223
16.

Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers, bulk RNA-seq

(Submitter supplied) Glutamine metabolism in the tumor microenvironment is emerging as a critical regulator of immune-mediated anti-tumor responses. We report potent tumor growth inhibition by the glutamine antagonist prodrug JHU083 in urologic tumors by JHU083-reprogrammed tumor-associated macrophages (TAMs) and tumor-infiltrating monocytes (TIMs). Using orthogonal approaches, we show that JHU083-mediated glutamine antagonism in the tumor microenvironment induces TNF, inflammatory, and mTORC1 signaling in different intra-tumoral TAM clusters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: RESULTS, TXT
Series
Accession:
GSE229222
ID:
200229222
17.

Transcriptome changes after overexpression, knockdown and condItional knockout of UXT in mice

(Submitter supplied) Ubiquitously expressed transcript (UXT) has been shown to play a role in regulating the process of autophagy. Here, we investigated roles of UXT in the innnate immune responses after overexpression, knockdown and condItional knockout of UXT in mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TXT
Series
Accession:
GSE175928
ID:
200175928
18.

Identification of functional genetic variants in transformed Ba/F3 cells expressing U2AF35(S34F)

(Submitter supplied) Exome and transcriptome sequencing analysis of murine transformed cells identifies loss of potential tumor suppressor
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: TXT
Series
Accession:
GSE115060
ID:
200115060
19.

Synthetic trimeric Interleukin-6 receptor complexes with a STAT3 phosphorylation dominated activation profile

(Submitter supplied) In Interleukin (IL)-6 signalling, IL-6 site I binds to the IL-6 receptor (IL-6R) first, following by IL-6 site II interaction to domain 2/3 of gp130 to form premature trimeric IL-6:IL‑6R:gp130 receptor complexes. Formation of the mature hexameric receptor complex is then facilitated by the inter-trimeric interaction of IL-6 site III with domain 1 of the opposing gp130. The two gp130-associated Janus kinases (JAKs) trans-phosphorylate when their spatiotemporal pairing is correct, which causes the activation of STAT, ERK, and AKT pathways in a balanced manner. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30172
16 Samples
Download data: XLSX
Series
Accession:
GSE267270
ID:
200267270
20.

Lack of TREM2 during anti-PD-1 therapy reprograms intestinal macrophages and microbiota to enhance tumor rejection

(Submitter supplied) The gut microbiota and tumor-associated macrophages (TAM) impact anti-PD-1 checkpoint blockade. Reprogramming TAM by either blocking or deleting the macrophage receptor TREM2 attenuates tumor growth, and lack of functional TREM2 enhances tumor elimination by anti-PD-1. Here, we found that anti-PD-1 combined with TREM2 deficiency induces proinflammatory programs in intestinal macrophages and a concomitant expansion of Ruminococcus gnavus (R. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
32 Samples
Download data: MTX, TSV
Series
Accession:
GSE262811
ID:
200262811
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid10090[Organism:noexp]|query=1|qty=1213|blobid=MCID_664b0e398626ff46af7bcc73|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center