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Items: 1 to 20 of 1345

1.

The chromatin loop release factor WAPL regulates EBV latency status by restricting LMP production

(Submitter supplied) Epstein-Barr virus (EBV) is a ubiquitous human pathogen that is etiologically linked to several cancers and has been connected to multiple sclerosis. EBV employs a series of latency programs, including latency III, latency II, and latency I, to persistently colonize the B-cell compartment. Each of these programs is associated with human malignancies. However, our understanding remains incomplete of how these distinct latency programs are epigenetically restricted. more...
Organism:
human gammaherpesvirus 4
Type:
Other
Platform:
GPL34401
4 Samples
Download data: TXT
Series
Accession:
GSE264502
ID:
200264502
2.

Aging aggravates aortic aneurysm and dissection via the miR-1204-MYLK signaling axis

(Submitter supplied) The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. more...
Organism:
Human alphaherpesvirus 2; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis
Type:
Non-coding RNA profiling by array
Platform:
GPL21439
12 Samples
Download data: GPR, XLSX
Series
Accession:
GSE253747
ID:
200253747
3.

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL34327 GPL18573
18 Samples
Download data: BW
Series
Accession:
GSE221625
ID:
200221625
4.

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells [EBV WGS]

(Submitter supplied) Epstein-Barr virus (EBV) is an etiologic risk factor, and likely prerequisite, for the development of multiple sclerosis (MS). However, the role of EBV infected B cells in the immunopathology of MS is not well understood. Here, we characterized spontaneous lymphoblastoid cell lines (SLCLs) isolated from MS patients and healthy controls (HC) ex vivo to study EBV and host gene expression in the context of an individual’s endogenous EBV. more...
Organism:
human gammaherpesvirus 4
Type:
Other
Platform:
GPL34327
9 Samples
Download data: BW, TXT
Series
Accession:
GSE221624
ID:
200221624
5.

A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency

(Submitter supplied) As a human tumor virus, EBV is present as a latent infection in its associated malignancies where genetic and epigenetic changes have been shown to impede cellular differentiation and viral reactivation. One such change is increased levels of the Wnt signaling effector, lymphoid enhancer binding factor 1 (LEF1) following EBV epithelial infection. In silico analysis of EBV type 1 and 2 genomes identified over 20 Wnt-response elements suggesting that LEF1 may directly bind the EBV genome and regulate the viral life cycle. more...
Organism:
human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL33849 GPL33850
31 Samples
Download data: BEDGRAPH
Series
Accession:
GSE245534
ID:
200245534
6.

Chronic Active Epstein-Barr Virus Disease Originates from Infected Hematopoietic Stem Cells

(Submitter supplied) Chronic active Epstein-Barr Virus (EBV) disease (CAEBV) is lethal syndrome due to persistent EBV infection. When diagnosed as CAEBV, EBV infection was observed in multiple hematopoietic lineages, but the etiology of CAEBV is still elusive. Bone marrow and peripheral cells derived from five CAEBV patients, one EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patient, and two healthy controls were analyzed. more...
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL33393 GPL24676
32 Samples
Download data: MTX, TSV
Series
Accession:
GSE231946
ID:
200231946
7.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL25190 GPL23185
29 Samples
Download data: BEDPE, BW, NARROWPEAK, TXT
Series
Accession:
GSE239995
ID:
200239995
8.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [RNA-seq]

(Submitter supplied) Epstein-Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its chromatinized episomes with the host genome. EBV exhibits different latency-associated transcriptional repertoires, each with distinct three-dimensional structures. CTCF, Cohesin and PARP1 are involved in maintaining viral latency and establishing episome architecture. Epstein-Barr virus-associated gastric cancer (EBVaGC) represents 1.3% to 30.9% of all gastric cancers globally. more...
Organism:
Homo sapiens; human gammaherpesvirus 4
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23185
3 Samples
Download data: TXT
Series
Accession:
GSE239994
ID:
200239994
9.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [HiChIP]

(Submitter supplied) Epstein-Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its chromatinized episomes with the host genome. EBV exhibits different latency-associated transcriptional repertoires, each with distinct three-dimensional structures. CTCF, Cohesin and PARP1 are involved in maintaining viral latency and establishing episome architecture. Epstein-Barr virus-associated gastric cancer (EBVaGC) represents 1.3% to 30.9% of all gastric cancers globally. more...
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Other
Platform:
GPL23185
4 Samples
Download data: BEDPE, TXT
Series
Accession:
GSE239992
ID:
200239992
10.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [HiC]

(Submitter supplied) Epstein-Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its chromatinized episomes with the host genome. EBV exhibits different latency-associated transcriptional repertoires, each with distinct three-dimensional structures. CTCF, Cohesin and PARP1 are involved in maintaining viral latency and establishing episome architecture. Epstein-Barr virus-associated gastric cancer (EBVaGC) represents 1.3% to 30.9% of all gastric cancers globally. more...
Organism:
human gammaherpesvirus 4
Type:
Other
Platform:
GPL25190
10 Samples
Download data: TXT
Series
Accession:
GSE239989
ID:
200239989
11.

The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [ChIP-seq]

(Submitter supplied) Epstein-Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its chromatinized episomes with the host genome. EBV exhibits different latency-associated transcriptional repertoires, each with distinct three-dimensional structures. CTCF, Cohesin and PARP1 are involved in maintaining viral latency and establishing episome architecture. Epstein-Barr virus-associated gastric cancer (EBVaGC) represents 1.3% to 30.9% of all gastric cancers globally. more...
Organism:
human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25190
12 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE239987
ID:
200239987
12.

Increased pro-inflammatory phenotype of peripheral blood monocytes and monocyte-derived macrophages among patients with excessive ethanol intake

(Submitter supplied) Excessive alcohol consumption adversely affects the immune system and triggers the activation of peripheral blood (PB) monocytes and tissue macrophages, contributing to alcohol- related organ damage. This study aimed to analyze the M1/M2 and inflammatory phenotypes of circulating monocytes and macrophage-derived monocytes (MDMs). This single-center cross- sectional study included 20 excessive alcohol drinkers (EADs) and 22 healthy controls. more...
Organism:
Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
22 Samples
Download data: GPR, TXT
Series
Accession:
GSE239659
ID:
200239659
13.

m6A modification of EBV transcripts

(Submitter supplied) We examined the viral epitranscriptome in EBV transformed lymphoblastoid cell lines (LcLs) and EBV-positive Burkitt's lymphoma, Akata cells, using methylated RNA immunoprecipitation followed by sequencing (MeRIP-seq). Biological replicates of ribo-RNA deleted mRNA of each cell type were prepared for MeRIP-seq followed by peak calling using the exome Peak package with settings for stringent peak calling on both strands of the genome.
Organism:
human gammaherpesvirus 4
Type:
Other
Platform:
GPL26377
16 Samples
Download data: CSV, TXT
Series
Accession:
GSE129217
ID:
200129217
14.

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer [ChIP-seq]

(Submitter supplied) To investigate the EBV genome after Decitabine treatment by CTCF ChIP-seq
Organism:
human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL33481
8 Samples
Download data: BW
Series
Accession:
GSE234603
ID:
200234603
15.

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL25190 GPL33481
30 Samples
Download data: BW
Series
Accession:
GSE239770
ID:
200239770
16.

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer [RNA]

(Submitter supplied) To investigate the EBV genome after Decitabine treatment by reduced representation bisulfite sequencing, ATAC-seq, and RNA-seq
Organism:
human gammaherpesvirus 4
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25190
18 Samples
Download data: BW, TXT
Series
Accession:
GSE239767
ID:
200239767
17.

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer [ATAC]

(Submitter supplied) To investigate the EBV genome after Decitabine treatment by reduced representation bisulfite sequencing, ATAC-seq, and RNA-seq
Organism:
human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL33481
12 Samples
Download data: BW
Series
Accession:
GSE239645
ID:
200239645
18.

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
human gammaherpesvirus 4
Type:
Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL25190 GPL33481
16 Samples
Download data: BW, COV
Series
Accession:
GSE234658
ID:
200234658
19.

Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer [RRBS]

(Submitter supplied) To investigate the EBV genome after Decitabine treatment by reduced representation bisulfite sequencing, ATAC-seq, and RNA-seq
Organism:
human gammaherpesvirus 4
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL25190
8 Samples
Download data: COV
Series
Accession:
GSE233330
ID:
200233330
20.

Single-Cell Transcriptomics of Epstein-Barr Virus and Human Herpesvirus 6 Coinfection

(Submitter supplied) Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) infection is widespread among people. Here I describe single-cell RNA sequencing of two lymphoblastoid cell lines harboring both episomal EBV and inherited chromosomally integrated HHV-6. Rare instances of HHV-6 expression appear enriched with EBV reactivation.
Organism:
human gammaherpesvirus 4; Human betaherpesvirus 6B; Homo sapiens; Human betaherpesvirus 6A
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL33373 GPL33355
2 Samples
Download data: H5
Series
Accession:
GSE230239
ID:
200230239
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