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Items: 1 to 20 of 138

1.

Spermine-induced DNA methylation change in human macrophages

(Submitter supplied) Polyamines, crucial molecules involved in cell proliferation and growth, play a pivotal role in cancer development and progression. Within the tumor microenvironment, macrophages, key components of the immune system, exhibit a complex relationship with polyamines. Evidence suggests that polyamines can modulate macrophage polarization, influencing their functional phenotypes. Here, we detected the gene DNA methylation changes in spermine-stimulated human macrophages isolated from PBMCs and TAMs.
Organism:
Campylobacter jejuni; Francisella tularensis subsp. novicida; Yersinia pestis; Staphylococcus aureus; Mycobacterium avium subsp. paratuberculosis; Cowpox virus; Escherichia coli O157:H7; Francisella tularensis subsp. mediasiatica; Paslahepevirus balayani; Yersinia enterocolitica; Toxoplasma gondii; Salmonella enterica subsp. enterica serovar Typhimurium; Mammarenavirus choriomeningitidis; Orthohantavirus puumalaense; Yersinia pseudotuberculosis; Rickettsia prowazekii; Bartonella quintana; Mycobacterium avium; Homo sapiens; Streptobacillus moniliformis; Bartonella henselae; Francisella tularensis subsp. tularensis; Francisella tularensis subsp. holarctica; Leptospira interrogans; Rickettsia typhi; Mycobacterium tuberculosis variant bovis; Mycobacterium tuberculosis; Mycobacterium tuberculosis variant microti; Mycobacterium canetti; Orthohantavirus seoulense
Type:
Methylation profiling by array
Platform:
GPL21445
4 Samples
Download data: IDAT, TXT
Series
Accession:
GSE267014
ID:
200267014
2.

Transcriptome RNA Sequencing Data Sets of Francisella tularensis tularensis SchuS4 upon treatment with various concentrations of Doxycycline or Ciprofloxacin antibiotics

(Submitter supplied) Francisella tularensis, the etiological agnet of Tularemia is a Category A select agent. Preparedness means for prompt proper antibiotic treatment are of need to prevent morbidity and mortality. While standard antimicrobial susceptibility tests are time consuming, the quantification of the changes in the expression levlels of specific mRNA markers folowing antibiotic exposure may enable a rapid determination of antimicrobial susceptibility. more...
Organism:
Francisella tularensis subsp. tularensis SCHU S4
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32560
12 Samples
Download data: TXT
Series
Accession:
GSE210974
ID:
200210974
3.

Arginine catabolism and polyamine biosynthesis pathway disparities within Francisella tularensis subpopulations

(Submitter supplied) Francisella tularensis is a highly infectious zoonotic pathogen with as few as 10 organisms causing tularemia, a disease that is fatal if untreated. Although F. tularensis subspecies tularensis (type A) and subspecies holarctica (type B) share over 99.5% average nucleotide identity, notable differences exist in genomic organization and pathogenicity. The type A clade has been further divided into subtypes A.I and A.II, with A.I strains being recognized as some of the most virulent bacterial pathogens known. more...
Organism:
Francisella tularensis subsp. holarctica; Francisella tularensis subsp. tularensis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL32256 GPL32255
96 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE202948
ID:
200202948
4.

Next Generation Sequencing (NGS) for quantitative transcriptomic analysis of Francisella strains (Francisella novicida, ribD-deficient Francisella novicida , Francisella tularensis)

(Submitter supplied) To understand differences of gene expression profiles between Francisella strains RNA profiles of Francisella strains were generated by deep sequencing, in triplicate, using NovaSeq6000. qRT–PCR validation was performed using SYBR Green assays. Our study represents the first detailed differential transcriptomic analysis of Francisella strains , with biologic replicates, generated by RNA-seq technology.
Organism:
Francisella tularensis subsp. novicida U112; Francisella tularensis subsp. tularensis SCHU S4
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL30175 GPL30176
9 Samples
Download data: TXT
Series
Accession:
GSE174793
ID:
200174793
5.

Single-cell transcriptomic profiling of healthy and fibrotic adult zebrafish liver reveals conserved cell identities and pathways with human liver

(Submitter supplied) Liver fibrosis is the excessive accumulation of extracellular matrix that can progress to cirrhosis and failure if untreated. The mechanisms of fibrogenesis are multi-faceted and remain elusive with no approved antifibrotic treatments available. Here we use single-cell RNA sequencing (scRNA-seq) of the adult zebrafish liver to study the molecular and cellular dynamics of the liver at a single-cell level and demonstrate the value of the adult zebrafish as a model for studying liver fibrosis. more...
Organism:
Danio rerio; Francisella tularensis subsp. tularensis SCHU S4
Type:
Expression profiling by high throughput sequencing; Third-party reanalysis
Platform:
GPL20828
6 Samples
Download data: MTX, RDS, TSV, TXT, XLSX
Series
Accession:
GSE181987
ID:
200181987
6.

Detection of a Yersinia pestis homologue in rodent samples

(Submitter supplied) A microarray was developed to screen rodent samples for pathogens of zoonotic importance In the work described here, a homologue to Yersinia pestis was found in rodent samples after screening with the microarray
Organism:
Yersinia enterocolitica; Rickettsia prowazekii; Rickettsia typhi; Mycobacterium tuberculosis variant bovis; Toxoplasma gondii; Apodemus sylvaticus; Salmonella enterica subsp. enterica serovar Typhimurium; Campylobacter jejuni; Yersinia pestis; Mycobacterium tuberculosis variant microti; Rattus rattus; Mycobacterium canetti; Francisella tularensis subsp. mediasiatica; Mammarenavirus choriomeningitidis; Orthohantavirus puumalaense; Orthohantavirus seoulense; Bartonella quintana; Staphylococcus aureus; Mycobacterium avium; Rattus norvegicus; Cowpox virus; Escherichia coli O157:H7; Francisella tularensis subsp. holarctica; Leptospira interrogans; Francisella tularensis subsp. novicida; Yersinia pseudotuberculosis; Mycobacterium avium subsp. paratuberculosis; Mycobacterium tuberculosis; Mus musculus; Streptobacillus moniliformis; Bartonella henselae; Francisella tularensis subsp. tularensis; Paslahepevirus balayani
Type:
Genome variation profiling by array
Platform:
GPL21445
65 Samples
Download data: TXT
Series
Accession:
GSE77765
ID:
200077765
7.

Expression data from multiple strains of Francisella

(Submitter supplied) Comparison of expression profiles of strains of Francisella to identify virulence factors We used custom microarrays to detail the global gene expression of four strains of Francisella (Schu4, LVS, OR960246, U112) and identified distinct classes of differentially expressed genes during this process.
Organism:
Francisella; Francisella tularensis subsp. novicida U112; Francisella tularensis subsp. holarctica LVS; Francisella tularensis subsp. holarctica OR96246; Francisella tularensis subsp. tularensis SCHU S4
Type:
Expression profiling by array
Platform:
GPL20119
12 Samples
Download data: CEL
Series
Accession:
GSE68478
ID:
200068478
8.

Francisella tularensis Schu4 gene expression during infection of mouse spleen

(Submitter supplied) Francisella tularensis is classified as a Category A priority pathogen and causes fatal disseminated disease in humans upon inhalation of less than 50 bacteria. Although drugs are available for treatment, they are not ideal because of toxicity and delivery, and in some cases relapse upon withdrawal. We have an ongoing program in the development of novel FabI enoyl-ACP-reductase enzyme inhibitors for Francisella and other select agents. more...
Organism:
Francisella tularensis subsp. tularensis SCHU S4
Type:
Expression profiling by array
Platform:
GPL15884
1 Sample
Download data: GPR, TXT
Series
Accession:
GSE39871
ID:
200039871
9.

virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages

(Submitter supplied) The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen, whose virulence requires proliferation inside host cells, including macrophages. Although some Francisella determinants of intracellular growth have been identified, much remains to be understood about the pathogenesis of this organism. In particular, how Francisella responds to its intracellular environment could provide clues about its intracellular biology and reveal pathogenic determinants based on their intracellular expression profiles. more...
Organism:
Borrelia hermsii; Burkholderia mallei; Francisella tularensis subsp. tularensis SCHU S4; Brucella suis; Francisella tularensis; Coxiella burnetii; Rickettsia prowazekii
Type:
Expression profiling by array
Platform:
GPL7246
32 Samples
Download data: CEL, CHP
Series
Accession:
GSE12663
ID:
200012663
10.

Illumina HiSeq 2000 (Francisella tularensis subsp. tularensis SCHU S4)

Organism:
Francisella tularensis subsp. tularensis SCHU S4
1 Series
12 Samples
Download data
Platform
Accession:
GPL32560
ID:
100032560
11.

Illumina NextSeq 500 (Francisella tularensis subsp. tularensis)

Organism:
Francisella tularensis subsp. tularensis
1 Series
72 Samples
Download data
Platform
Accession:
GPL32256
ID:
100032256
12.

Illumina NovaSeq 6000 (Francisella tularensis subsp. tularensis SCHU S4)

Organism:
Francisella tularensis subsp. tularensis SCHU S4
1 Series
3 Samples
Download data
Platform
Accession:
GPL30176
ID:
100030176
13.

WT_Rodent_Chip_03

(Submitter supplied) Oligonucleotides were purchased as 3′-amino-modified oligos from Metabion (Martinsried, Germany) and applied at a final concentration of 10 μM in Spotting Buffer 1 (Quantifoil Micro Tools, Jena, Germany). Arrays were spotted using a Microgrid II spotting machine (BioRobotics Inc., Cambridge, UK) according to the instructions of the manufacturer and assembled into ArrayStrips. Each oligonucleotide probe was replicated two-fold on the array. more...
Organism:
Leptospira interrogans; Campylobacter jejuni; Francisella tularensis subsp. novicida; Yersinia enterocolitica; Yersinia pestis; Yersinia pseudotuberculosis; Rickettsia prowazekii; Rickettsia typhi; Bartonella quintana; Staphylococcus aureus; Mycobacterium avium; Mycobacterium tuberculosis variant bovis; Mycobacterium avium subsp. paratuberculosis; Mycobacterium tuberculosis; Mycobacterium tuberculosis variant microti; Toxoplasma gondii; Cowpox virus; Streptobacillus moniliformis; Bartonella henselae; Mycobacterium canetti; Escherichia coli O157:H7; Salmonella enterica subsp. enterica serovar Typhimurium; Francisella tularensis subsp. tularensis; Francisella tularensis subsp. holarctica; Francisella tularensis subsp. mediasiatica; Paslahepevirus balayani; Mammarenavirus choriomeningitidis; Orthohantavirus puumalaense; Orthohantavirus seoulense
2 Series
69 Samples
Download data
Platform
Accession:
GPL21445
ID:
100021445
14.

Rocky Mountain Regional Center for Excellence Francisella tularensis full genome array

(Submitter supplied) http://www.operon.com/products/microarrays/oparrays_download.aspx
Organism:
Francisella tularensis subsp. tularensis SCHU S4
1 Series
1 Related Platform
1 Sample
Download data
Platform
Accession:
GPL15884
ID:
100015884
15.

Rocky Mountain Regional Center for Excellence Francisella tularensis full genome array (FTT version)

(Submitter supplied) http://www.operon.com/products/microarrays/oparrays_download.aspx
Organism:
Francisella tularensis subsp. tularensis SCHU S4
1 Related Platform
Download data
Platform
Accession:
GPL15812
ID:
100015812
16.

F. tularensis 2 hours post exposure to 0.016 µg/ml (1xMIC) Ciprofloxacin 2nd duplicate

Organism:
Francisella tularensis subsp. tularensis SCHU S4
Source name:
WT Bacteria
Platform:
GPL32560
Series:
GSE210974
Download data
Sample
Accession:
GSM6443570
ID:
306443570
17.

F. tularensis 2 hours post exposure to 0.016 µg/ml (1xMIC) Ciprofloxacin 1st duplicate

Organism:
Francisella tularensis subsp. tularensis SCHU S4
Source name:
WT Bacteria
Platform:
GPL32560
Series:
GSE210974
Download data
Sample
Accession:
GSM6443569
ID:
306443569
18.

F. tularensis 2 hours post exposure to 0.008 µg/ml (0.5xMIC) Ciprofloxacin 2nd duplicate

Organism:
Francisella tularensis subsp. tularensis SCHU S4
Source name:
WT Bacteria
Platform:
GPL32560
Series:
GSE210974
Download data
Sample
Accession:
GSM6443568
ID:
306443568
19.

F. tularensis 2 hours post exposure to 0.008 µg/ml (0.5xMIC) Ciprofloxacin 1st duplicate

Organism:
Francisella tularensis subsp. tularensis SCHU S4
Source name:
WT Bacteria
Platform:
GPL32560
Series:
GSE210974
Download data
Sample
Accession:
GSM6443567
ID:
306443567
20.

F. tularensis 2 hours post exposure to 0.25 µg/ml (1xMIC) Doxycycline 2nd duplicate

Organism:
Francisella tularensis subsp. tularensis SCHU S4
Source name:
WT Bacteria
Platform:
GPL32560
Series:
GSE210974
Download data
Sample
Accession:
GSM6443566
ID:
306443566
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