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Items: 1 to 20 of 2279

1.

A comprehensive analysis of pneumcoccal two-component system regulatory networks

(Submitter supplied) This study investigates the regulons of 11 pneumococcal response regulators (RRs) by RNA-sequencing of RR-overexpression mutants.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28680
36 Samples
Download data: CSV
Series
Accession:
GSE225902
ID:
200225902
2.

Impact of DFMO and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae

(Submitter supplied) Streptococcus pneumoniae (Spn), a Gram-positive bacterium, poses a significant threat to human health, causing mild respiratory infections to severe invasive conditions. Despite availability of vaccines, challenges persist due to serotype replacement and antibiotic resistance, emphasizing the need for alternative therapeutic strategies. This study explores the intriguing role of polyamines, ubiquitous, small organic cations, in modulating virulence factors, especially the capsule, a crucial determinant of Spn's pathogenicity. more...
Organism:
Streptococcus pneumoniae D39
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34053
12 Samples
Download data: CSV
Series
Accession:
GSE252370
ID:
200252370
3.

Extracellular phosphate is involved in the virulence regulation of Streptococcus pneumoniae

(Submitter supplied) The gene expression of S. pneumoniae cultured in medium with different concentration of phosphate were detected, aiming to analyze the role of reduced extracellular phosphate in virluence regulation of S. pneumoniae.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23152
2 Samples
Download data: CSV, XLS
Series
Accession:
GSE221902
ID:
200221902
4.

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae

(Submitter supplied) We obtained the topARA mutant that encodes a TopoI enzyme that shows reduced topoisomerase activity compared to the wild type gene (topAWT) and confers resistance to the antibiotic seconeolitsine. Alterations in the gene expression profile produced after overexpression of the wild type or the RA mutant of topA gene were studied. In addition, differential gene expression produced by the DNA gyrase inhibitor novobiocin (NOV) was also studied in cultures overexpressing each of the versions of TopA.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28680
16 Samples
Download data: TXT
Series
Accession:
GSE243041
ID:
200243041
5.

Effect on gene expression of addition of N-acetylmannosamine to galactose grown Streptococcus pneumoniae.

(Submitter supplied) RNA-seq analysis of N-acetylmannosamine upon growth and gene expression in pneumococci grown with galactose as sole sugar.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22606
12 Samples
Download data: TXT
Series
Accession:
GSE246424
ID:
200246424
6.

Impact of Endogenous Pneumococcal Hydrogen Peroxide on the activity and release of Pneumolysin

(Submitter supplied) Streptococcus pneumoniae is the leading cause of community-acquired pneumonia. The release of the pore-forming cholesterol-dependent cytolysin (CDC) pneumolysin (PLY) and hydrogen peroxide (H2O2), a physiological metabolite, is an important virulence determinant of pneumococci.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23797
10 Samples
Download data: TXT
Series
Accession:
GSE240442
ID:
200240442
7.

Effect of knockout and overexpression of the Streptococcus pneumoniae topoisomerase I regulator StaR on gene expression.

(Submitter supplied) Strain ∆staRPZnstaR was obtained to investigate genome-wide differential gene expresion when staR gene is reppressed or overexpressed by adding Zn to the culture medium. In addition, gene expression profile alterations produced upon inhibition of gyrase with Novobiocin were studied in the absence and presence of StaR.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28680
8 Samples
Download data: TXT
Series
Accession:
GSE225261
ID:
200225261
8.

Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell

(Submitter supplied) Deep sequencing of cDNA from Streptococcus pneumoniae EF3030 bacteria and normalized human broncial epithelial cells (nHBEC), alone, together, and after coincubation with Influenza A virus pH1N1.
Organism:
Influenza A virus; Streptococcus pneumoniae; Homo sapiens
Type:
Expression profiling by high throughput sequencing
5 related Platforms
14 Samples
Download data: MATRIX
Series
Accession:
GSE225108
ID:
200225108
9.

Global transcriptional responses of pneumococcus to human blood components and cerebrospinal fluid

(Submitter supplied) This study investigates the global transcriptional response of Streptococcus pneumoniae D39V (serotype 2 strain) to human blood components and CSF acquired from discarded and anonymized patient samples.
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28680
30 Samples
Download data: CSV, GFF3
Series
Accession:
GSE214359
ID:
200214359
10.

RNA-seq IU10991 vs IU1781

(Submitter supplied) Here we analyze the transcriptomic profile of Streptococcus pneumoniae D39 Dspd_1448::KanrpsL (IU10991) vs Streptcococcus penumoiae D39 wt (IU1781) under anaerobic growth condition in BHI growth media
Organism:
Streptococcus pneumoniae D39
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24384
6 Samples
Download data: TXT
Series
Accession:
GSE196501
ID:
200196501
11.

Methionine starvation caused reprogrammed metabolism in Streptococcus pneumoniae

(Submitter supplied) In our study, deletion of methionine synthesis gene metE (SPD_0510) impaired the growth of Streptococcus pneumoniae strain D39 significantly when bacteria were cultured in chemically defined medium with a low concentration of methionine. Bacteria undergo methionine starvation in this condition. We aimed to know how S. pneumoniae responses to methionine starvation, particularly at the transcriptional level. more...
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28680
4 Samples
Download data: XLSX
Series
Accession:
GSE184094
ID:
200184094
12.

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

(Submitter supplied) This study reports on the co-administration of a zinc ionophore (PBT-2) and ampicillin to break antibiotic resistance of Streptococcus pneumoniae in a murine pneumonia model. The molecular mechanism for this heightened antimicrobial activity was identified through transcriptomic and metabolomic analyses of a wild type strain and a zinc efflux mutant to identify cellular targets of zinc intoxication. more...
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23152
3 Samples
Download data: TXT, XLSX
Series
Accession:
GSE159901
ID:
200159901
13.

Streptococcus pneumoniae strain D39V were grown in six different conditions, mimicking the host niches

(Submitter supplied) Streptococcus pneumoniae strain D39V were grown in six different conditions, mimicking the host niches
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26308
18 Samples
Download data: TXT
Series
Accession:
GSE128366
ID:
200128366
14.

Dual RNA-seq on pneumococcal infection to zebrafish embryo model

(Submitter supplied) Zebrafish embryo has been emerging as an interesting model of infection due to their fecundity, transparency and availability of genetic tools. Streptococcus pneumoniae, the pneumococcus, is the main etiological agent of pneumonia, sepsis and meningitis. The bacteria expresses a very important virulence factor, pneumolysin able to form pores on cholesterol-based membranes and to activate innate immune system. more...
Organism:
Streptococcus pneumoniae; Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25946
6 Samples
Download data: TXT
Series
Accession:
GSE123988
ID:
200123988
15.

Glutamate dehydrogenase (GdhA) of S. pneumoniae is required for high temperature adaptation

(Submitter supplied) During its progression from nasopharynx to other sterile and non-sterile niches of its human host, Streptococcus pneumoniae must cope with changes in temperature. We hypothesized that the pneumococcal temperature adaptation is an important facet of pneumococcal in host survival. Here we evaluate the effect of temperature on the phenotype of pneumococcus and the role of glutamate dehydrogenase (GdhA) during thermal stress adaptation associated with virulence and survival. more...
Organism:
Streptococcus pneumoniae D39
Type:
Expression profiling by array
Platform:
GPL22631
8 Samples
Download data: TXT
Series
Accession:
GSE154888
ID:
200154888
16.

Anatomical Site-Specific Carbohydrate Availability Impacts Streptococcus pneumoniae Virulence and Fitness during Colonization and Disease

(Submitter supplied) Transcriptomic analysis of Streptococcus pneumoniae TIGR4 wildtype and it's isogenic ccpA mutant, grown in chemically defined media supplemented with physiological levels of carbohydrates to mimic the human nasopharynx and bloodstream. The goal is to examine how anatomical site-specific carbohydrate availability impacts S. pneumoniae physiology and virulence.
Organism:
Streptococcus pneumoniae TIGR4
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30972
10 Samples
Download data: TXT
Series
Accession:
GSE189057
ID:
200189057
17.

RNAseq transcriptome analysis of Streptococcus pneumoniae 23F treated with PBT2 and zinc

(Submitter supplied) Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response uses various chemical insults to control infection, including metal stress mediated by localized changes in zinc abundance. Here, we characterized the impact of S. pneumoniae zinc intoxication revealing disruptions in central carbon metabolism, lipid biogenesis and peptidoglycan biosynthesis. more...
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23152
6 Samples
Download data: XLSX
Series
Accession:
GSE160372
ID:
200160372
18.

Pivotal Roles for Ribonucleases in Streptococcus pneumoniae Pathogenesis

(Submitter supplied) RNases perform indispensable functions in regulating gene expression in many bacterial pathogens by processing and/or degrading RNAs. Despite the pivotal role of RNases in regulating bacterial virulence factors, the functions of RNases have not yet been studied in the major human respiratory pathogen Streptococcus pneumoniae (pneumococcus). Here, we sought to determine the impact of two conserved RNases, the endoribonuclease RNase Y and exoribonuclease polynucleotide phosphorylase (PNPase), on the physiology and virulence of S. more...
Organism:
Streptococcus pneumoniae D39
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL25906 GPL22880
15 Samples
Download data: XLSX
Series
Accession:
GSE173392
ID:
200173392
19.

Bioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative - Streptococcus pneumoniae 947

(Submitter supplied) The Antibiotic Resistant Sepsis Pathogens Framework Initiative aims to develop a framework dataset of 5 sepsis pathogens (5 strains each) using an integrated application of genomic, transcriptomic, metabolomic and proteomic technologies. The pathogens included in this initiative are: Escherichia coli, Klebsiella pneumoniae complex, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae. more...
Organism:
Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23152
18 Samples
Download data: GFF, GTF, TXT
Series
Accession:
GSE152965
ID:
200152965
20.

Bioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Streptococcus pyogenes; Klebsiella variicola; Klebsiella pneumoniae; Escherichia coli; Staphylococcus aureus; Streptococcus pneumoniae
Type:
Expression profiling by high throughput sequencing
6 related Platforms
329 Samples
Download data
Series
Accession:
GSE152848
ID:
200152848
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