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Items: 1 to 20 of 973

1.

The HtrA chaperone monitors sortase-assembled pilus biogenesis in E. faecalis

(Submitter supplied) Sortase-assembled pili contribute to virulence in many Gram-positive bacteria. In Enterococcus faecalis, the endocarditis and biofilm-associated pilus (Ebp) is polymerized on the membrane by sortase C (SrtC) and attached to the cell wall by sortase A (SrtA). In the absence of SrtA, polymerized pili remain anchored to the membrane (i.e. off-pathway). Here we show that the high temperature requirement A (HtrA) bifunctional chaperone/protease of E. more...
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18799 GPL24867
33 Samples
Download data: XLSX
Series
Accession:
GSE261583
ID:
200261583
2.

Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis

(Submitter supplied) Enterococcus faecalis is a commensal bacterium in the gastrointestinal tract (GIT) of humans and other organisms. Outside of the GIT, E. faecalis can cause infections in root canals, wounds, surgical sites, the urinary tract, and on heart valves. Many of these infections can be polymicrobial, and a variety of toxins and nutritional signals influence interactions between E. faecalis and other microbes. more...
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL31169
8 Samples
Download data: TXT
Series
Accession:
GSE268264
ID:
200268264
3.

YvcL-regulated genes in Enterococcus faecalis

(Submitter supplied) The goal was to identify genes regulated by YvcL (EF0768) by assessing changes in the yvcL deletion mutant relative to the isogenic wild-type. Wild-type E. faecalis OG1 and the mutant lacking yvcL were cultured in Mueller-Hinton broth to exponential phase. Total RNA was purified, depleted for rRNA, and subjected to preparation of mRNA libraries.
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28666
8 Samples
Download data: TXT
Series
Accession:
GSE234500
ID:
200234500
4.

Purine and carbohydrate availability drive Enterococcus faecalis fitness in wound infections.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23172
20 Samples
Download data
Series
Accession:
GSE206751
ID:
200206751
5.

Purine  and carbohydrate availability drive Enterococcus faecalis fitness in wound infections [dataset 2]

(Submitter supplied) Enterococcus faecalis is commonly isolated from different wound types. However, despite its prevalence, the pathogenic mechanisms of E. faecalis during wound infections remain poorly understood. We adopted an in vivo E. faecalis transposon sequencing and RNA sequencing approach to identify fitness determinants that are crucial for replication and persistence of E. faecalis during wound infections in a mouse model. more...
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23172
12 Samples
Download data: TXT
Series
Accession:
GSE206750
ID:
200206750
6.

Purine  and carbohydrate availability drive Enterococcus faecalis fitness in wound infections [dataset 1]

(Submitter supplied) Enterococcus faecalis is commonly isolated from different wound types. However, despite its prevalence, the pathogenic mechanisms of E. faecalis during wound infections remain poorly understood. We adopted an in vivo E. faecalis transposon sequencing and RNA sequencing approach to identify fitness determinants that are crucial for replication and persistence of E. faecalis during wound infections in a mouse model. more...
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23172
8 Samples
Download data: TXT
Series
Accession:
GSE206749
ID:
200206749
7.

RNAseq of WT pMSP3535-PnisA-6his-ftsH(H456Y) and WT pMSP3535-PnisA-6his-ftsH

(Submitter supplied) We report the transcriptome of cultures of WT pMSP3535-PnisA-6his-ftsH(H456Y) and WT pMSP3535-PnisA-6his-ftsH following overnight induction with 125 ng/mL nisin
Organism:
Enterococcus faecalis OG1RF
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32192
6 Samples
Download data: TXT
Series
Accession:
GSE201323
ID:
200201323
8.

Comparison of methods to generate a pooled Enterococcus faecalis Tn library from arrayed library plates

(Submitter supplied) The goal of this study was to determine how the method of pooling (combining mutants) for bacteral Tn libraries affected mutant distribution. Previously we generated a pooled version of a~6,800 Tn mutant library in Enterococcus faecalis OG1RF by plating and scraping individual mutants. Here, we combined liquid cultures grown in deep well plates. DNA from the new pooled library was extracted, and TnSeq was used to compare mutant distribution between the old (plate scraping) and new (liquid pooling) Tn library formats. more...
Organism:
Enterococcus faecalis
Type:
Other
Platform:
GPL30343
3 Samples
Download data: TXT
Series
Accession:
GSE233193
ID:
200233193
9.

Gene expression profiles of differentially expressed genes in Enterococcus faecalis 14 ΔpnpA mutant strain

(Submitter supplied) To explain the particular behavior of the mutant ΔpnpA strain, we performed a comparative transciptomic analysis of RNA isolated from a derivative strain ΔpnpA mutant versus the wild-type (WT) , after 3h and 6 h of growth in GM17 medium under semi-aerobic conditions.
Organism:
Enterococcus faecalis
Type:
Expression profiling by array
Platform:
GPL28480
12 Samples
Download data: GPR, XLSX
Series
Accession:
GSE180397
ID:
200180397
10.

RNA degradation analysis reveals ribosome dynamics in complex microbiome samples

(Submitter supplied) The microbiome has revealed itself as a key player in health and disease. To better understand its role, in addition to microbial diversity, it is important to understand species-specific activity and gene expression. While metatranscriptomics investigates mRNA abundance2, it does not inform about faster post-transcriptional regulation3. Although prokaryotic translation is a common target for antibiotics, a direct measurement of microbiome ribosome dynamics remains inaccessible. more...
Organism:
Segatella copri; Alistipes finegoldii; Hoylesella timonensis; compost metagenome; Escherichia coli; Synechocystis sp. PCC 6803; Staphylococcus aureus; Bacillus amyloliquefaciens; Lactiplantibacillus plantarum; Cryptococcus neoformans; Caulobacter vibrioides; Enterococcus faecalis; Bacillus subtilis; Limosilactobacillus reuteri; Limosilactobacillus fermentum; human feces metagenome; Listeria monocytogenes; Saccharomyces cerevisiae; Salmonella enterica; Parabacteroides merdae
Type:
Other
17 related Platforms
199 Samples
Download data: BEDGRAPH, TXT, XLSX
Series
Accession:
GSE153497
ID:
200153497
11.

Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states

(Submitter supplied) In this study, we introduce BacDrop, a bacterial droplet-based high throughput scRNA-seq technology that can be applied to large cell numbers. We applied BacDrop to study Klebsiella pneumoniae clinical isolates and elucidated their critical, genome-wide heterogeneity in the absence and presence of antibiotic perturbations.
Organism:
Pseudomonas aeruginosa; Klebsiella pneumoniae; Escherichia coli; Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
5 related Platforms
35 Samples
Download data: TSV, TXT
Series
Accession:
GSE180237
ID:
200180237
12.

The impact of iron depletion on the transcriptome of Enterococcus faecalis

(Submitter supplied) To identify the genes and pathways utilized by E. faecalis to grow under iron starvation, we used RNA deep sequencing (RNA-seq) to compare the transscriptome of the parent strain OG1RF grown to mid-log in the chemically defined FMC medium with or without the addition of FeSO4 as an iron source.
Organism:
Enterococcus faecalis OG1RF
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32954
6 Samples
Download data: CSV
Series
Accession:
GSE221057
ID:
200221057
13.

Enterococcus Grad-seq and KhpB RIP-seq

(Submitter supplied) We investigated the RNA-protein interactome of Enterococcus faecalis V583 and Enterococcus faecium Aus0004 by native gradient fractionation of complexes coupled to RNA-sequencing. Whole bacterial cell lysates were analysed by size and density in a glycerol gradient. At native conditions, RNA-protein complexes stay intact and sediment as a whole. Sedimentation profiles of individual RNAs appear correlated in case of interaction in a complex. more...
Organism:
Enterococcus faecium Aus0004; Enterococcus faecalis V583
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL25048 GPL25049
46 Samples
Download data: FASTA, GFF, WIG
Series
Accession:
GSE196534
ID:
200196534
14.

Transcriptional Profiling of Enterococcus faecalis During Surface Penetration

(Submitter supplied) To investigate the transcriptional changes that Enterococcus faecalis undergoes during agar surface-penetration, which promote cell envelope remodeling and tolerance to stress.
Organism:
Enterococcus faecalis OG1RF
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32603
18 Samples
Download data: XLSX
Series
Accession:
GSE212145
ID:
200212145
15.

Enterococci enhance Clostridioides difficile pathogenesis

(Submitter supplied) Clostridioides difficile is one of the most common nosocomial pathogens and a global public health threat. Upon colonization of the gastrointestinal tract, C. difficile is exposed to a rapidly changing polymicrobial environment and a dynamic metabolic milieu. Despite the link between the gut microbiota and susceptibility to C. difficile, the impact of synergistic interactions between the microbiota and pathogens on the outcome of infection is largely unknown. more...
Organism:
Enterococcus faecalis; Clostridioides difficile
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL29669 GPL22510 GPL23172
9 Samples
Download data: BW, TSV
Series
Accession:
GSE165751
ID:
200165751
16.

CroR-regulated genes in Enterococcus faecalis OG1

(Submitter supplied) The goal was to identify genes that are regulated by cell wall stress (bacitracin treatment) in wild-type cells but not in mutant cells lacking CroR, thereby revealing genes of the CroR regulon. Cells of a mutant lacking CroR or its otherwise isogenic wild-type E. faecalis OG1 were cultured in Mueller-Hinton broth and treated (or not) with bacitracin for 15 min. Total RNA was purified, depleted for rRNA, and subjected to preparation of TruSeq stranded mRNA libraries before sequencing on a NextSeq 550 (76-bp single read run).
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL31169
16 Samples
Download data: TXT
Series
Accession:
GSE193042
ID:
200193042
17.

Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in mixed-species interactions

(Submitter supplied) Enterococcus faecalis is often co-isolated with Pseudomonas aeruginosa in mixed-species biofilm-associated infections of wounds and the urinary tract. As a defence strategy, the host innately restricts iron availability at infection sites. Despite their co-prevalence, the polymicrobial interactions of these two pathogens in low iron conditions, such as those found in the host, remains unexplored. Here we show that E. more...
Organism:
Pseudomonas aeruginosa; Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23172 GPL31024 GPL18287
30 Samples
Download data: TXT
Series
Accession:
GSE190090
ID:
200190090
18.

Contrasted effects of deoxycholate and taurocholate bile acids on the gut pathobiont Enterococcus faecalis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL31131 GPL23172
45 Samples
Download data
Series
Accession:
GSE194011
ID:
200194011
19.

Taurocholate acid signals a specific gene expression reprogramming affecting amino-acids and nucleotides metabolisms

(Submitter supplied) Enterococcus faecalis is a natural inhabitant of the human gastrointestinal tract. In a healthy physiological state of the gut (eubiosis), E. faecalis is a subdominant species in the intestinal microbiota. When the intestinal homeostasis is disrupted (dysbiosis), it becomes dominant species and can cause infections. The taurocholate bile acid (TCA) becomes prominent during dysbiosis. This experiment aimed to better understand how E. more...
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23172
20 Samples
Download data: TXT
Series
Accession:
GSE194009
ID:
200194009
20.

Gene expression in response to deoxycholate acid constraints growth of Enterococcus faecalis

(Submitter supplied) Enterococcus faecalis is a natural inhabitant of the human gastrointestinal tract. In a healthy physiological state of the gut (eubiosis), E. faecalis is a subdominant species in the intestinal microbiota. When the intestinal homeostasis is disrupted (dysbiosis), it becomes dominant species and can cause infections. The prominence of bile acids deoxycholate (DCA) hallmarks eubiosis. This experiment aimed to better understand how E. more...
Organism:
Enterococcus faecalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL31131
25 Samples
Download data: TXT
Series
Accession:
GSE192438
ID:
200192438
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