GEO DataSets

(Submitter supplied) Efficient assimilation of renewable feedstocks is the cornerstone for achieving sustainable and economical microbial production of commodity chemicals. Unfortunately, most renewables are foreign to the cellular metabolism of classical industrial workhorses, resulting in unsatisfactory biomanufacturing performance. Here, Corynebacterium glutamicum was systematically engineered for rapid non-natural xylose metabolism and the underlying adaptations were elucidated by combining metabolic engineering, adaptive laboratory evolution and systems biology techniques. more...

Organism:

Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30649

9 Samples

Download data: XLS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL29897

1214 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of C. glutamicum wild-type and mutant strains grown under different conditions.

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL29897

287 Samples

Download data

(Submitter supplied) Transcriptional profiling of C. glutamicum wild-type and mutant strains grown under different conditions.

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL29897

927 Samples

Download data: GPR, TXT, XLS

(Submitter supplied) Investigation of the impact of an overexpression of cg1978 on gene expression under standard conditions (CGXII-Glucose)

Organism:

Pseudomonas putida KT2440; Gluconobacter oxydans; Escherichia coli; Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032; Bacillus subtilis subsp. subtilis str. 168

Type:

Expression profiling by array

Platform:

GPL26911

3 Samples

Download data: GPR

(Submitter supplied) Cell proliferation is achieved by numerous enzyme reactions. Temperature governs the activity of each enzyme, which overall determines the optimal growth temperature. Synthesizing useful chemicals and fuels utilizes only part of the metabolic pathways, especially the central metabolic pathways such as glycolysis and TCA cycle to metabolize glucose. However, the optimal temperature for the activity of the central metabolic pathways is inconclusive whether it is correlated with the optimal temperature for cell proliferation. more...

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL25854

3 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Gluconobacter oxydans; Corynebacterium glutamicum ATCC 13032; Pseudomonas putida; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli; Corynebacterium glutamicum

Type:

Expression profiling by array

Platforms:

GPL22794 GPL22792

6 Samples

Download data: GPR

(Submitter supplied) Iron is the fourth most abundant element in the Earth’s crust. However, the poor solubility of iron due to oxidation of ferrous iron to the almost insoluble ferric iron under aerobic conditions constitutes a considerable challenge for living organisms to obtain sufficient amounts of the iron available. In the present study, we set out to characterize the global gene expression of C. glutamicum under iron limitation in comparison to iron-replete conditions.

Organism:

Escherichia coli; Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032; Bacillus subtilis subsp. subtilis str. 168; Pseudomonas putida; Gluconobacter oxydans

Type:

Expression profiling by array

Platform:

GPL22794

3 Samples

Download data: GPR

(Submitter supplied) Iron is the fourth most abundant element in the Earth’s crust. However, the poor solubility of iron due to oxidation of ferrous iron to the almost insoluble ferric iron under aerobic conditions constitutes a considerable challenge for living organisms to obtain sufficient amounts of the iron available. In the present study, we set out to characterize the global gene expression of C. glutamicum under iron limitation in comparison to iron-replete conditions.

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032; Gluconobacter oxydans; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli

Type:

Expression profiling by array

Platform:

GPL22792

3 Samples

Download data: GPR

(Submitter supplied) High level secretion of proteins via the Sec protein export pathway leads to secretion stress, a phenomenon that is thought to be caused by the accumulation of incompletely or misfolded proteins at the membrane-cell envelope interface. We have analyzed the transcriptional responses of C. glutamicum to the secretory production of two different heterologous proteins and found that, in both cases, the expression of the gene encoding a homologue of the extracytosolic HtrA protease was highly upregulated.

Organism:

Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL9860

9 Samples

Download data: GPR, XLSX

(Submitter supplied) The cAMP-dependent transcriptional regulator GlxR serves as a central hub in the regulatory network of the actinobacterial model organism Corynebacterium glutamicum and controls expression of ~10% of all genes. The consequences of a lowered cAMP level are mostly unkown. A single gene (cyaB) for a cAMP-synthesizing adenylate cyclase was identified and it had been reported that a cyaB mutant grows like the wild type on glucose, but has a strong growth defect in the presence of acetate. more...

Organism:

Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL9860

3 Samples

Download data: GPR, XLSX

(Submitter supplied) The pyruvate dehydrogenase complex (PDHC) catalyzes the oxidative decarboxylation of pyruvate yielding acetyl-CoA and CO2. The PDHC-deficient Corynebacterium glutamicum strain ΔaceE is therefore lacking an important decarboxylation step in central metabolism. Additional inactivation of pyc, encoding pyruvate carboxylase, resulted in a >15 hour lag phase in the presence of glucose, while no growth defect was observed on gluconeogenetic substrates like acetate. more...

Organism:

Gluconobacter oxydans; Pseudomonas putida KT2440; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli; Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL26911

3 Samples

Download data: GPR

(Submitter supplied) In summary, we have identified and characterized FtsR as a transcriptional activator of the essential cell division protein FtsZ in C. glutamicum, providing a novel regulatory player in the process of cell division.

Organism:

Gluconobacter oxydans; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli; Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL16989

3 Samples

Download data: GPR

(Submitter supplied) Investigation of the impact of an overexpression of malR (cg3315) on gene expression under standard conditions (CGXII-Glucose)

Organism:

Gluconobacter oxydans; Corynebacterium glutamicum ATCC 13032; Bacillus subtilis subsp. subtilis str. 168; Escherichia coli; Corynebacterium glutamicum

Type:

Expression profiling by array

Platform:

GPL22561

3 Samples

Download data: GPR

(Submitter supplied) We evaluated how HrrA binding (found by ChAP-Seq) impacts the expression of individual target genes, by analyzing the transcriptome of the C. glutamicum wild type strain (ATCC 13032) as well as a ∆hrrA mutant. RNA-Seq analysis was performed prior to the addition of heme (T0) and 0.5 and 4 h after the heme pulse (in medium containing no other iron source).

Organism:

Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25416

6 Samples

Download data: TSV

(Submitter supplied) The dicarboxylic acid glutarate is gaining attention in the chemical and pharmaceutical industry as promising building-block. Synthesis of glutarate via microbial fermentation is a desirable aim which will allow the production of biopolymers avoiding fossil raw materials. Here, by rational metabolic engineering of the biofactory microorganism Corynebacterium glutamicum the fermentative production of glutarate from glucose was established. more...

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL21055

3 Samples

Download data: TXT, XLSX

(Submitter supplied) To identify genes which are differentially expressed in Corynebacterium glutamicum in the cg2699 deletion strain, we performed DNA microarray analyses of C. glutamicum Δcg2699 compared to the WT.

Organism:

Gluconobacter oxydans; Corynebacterium glutamicum ATCC 13032; Escherichia coli; Corynebacterium glutamicum; Bacillus subtilis subsp. subtilis str. 168

Type:

Expression profiling by array

Platform:

GPL16989

3 Samples

Download data: GPR

(Submitter supplied) To identify genes which are differentially expressed in Corynebacterium glutamicum in the absence of copper, we performed DNA microarray analyses of cells cultivated under copper starvation conditions compared to copper sufficiency.

Organism:

Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL15451

3 Samples

Download data: GPR

(Submitter supplied) When the cell envelope integrity is compromised, bacteria trigger signaling cascades that result in the production of proteins that counteract these extracytoplasmic stresses. Here, we show that the two-component system EsrSR regulates a cell envelope stress response in the Actinobacterium Corynebacterium glutamicum. The sensor kinase EsrS possesses an amino-terminal phage shock protein C (PspC) domain, a property that sets EsrSR apart from all other two-component systems characterized so far. more...

Organism:

Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL9860

9 Samples

Download data: GPR

(Submitter supplied) Corynebacterium glutamicum can survive by using ferulic acid as the sole carbon source. In this study, we assessed the response of C.glutamicum to ferulic acid stress by means of a global transcriptional response analysis. The transcriptional data showed that several genes involved in degradation of ferulic acid were affected. Moreover, several genes related to the stress response; protein protection or degradation and DNA repair; replication, transcription and translation; and the cell envelope were differentially expressed. more...

Organism:

Corynebacterium glutamicum ATCC 13032

Type:

Expression profiling by array

Platform:

GPL22357

5 Samples

Download data: TXT