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Items: 1 to 20 of 765

1.

MicroRNA array studies in Hirschsprung disease

(Submitter supplied) To address the role of miRNAs in Hirschsprund disease (HSCR), we carried out microRNA (miRNA) array analysis by using human intestinal samples obtained from HSCR patients and controls, and identified dysregulated miRNAs involved in the pathogenesis of HSCR.
Organism:
Herpesvirus saimiri (strain 11); Homo sapiens; JC polyomavirus; Human gammaherpesvirus 8; Merkel cell polyomavirus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Human betaherpesvirus 6B
Type:
Non-coding RNA profiling by array
Platform:
GPL32145
10 Samples
Download data: GPR, TXT
Series
Accession:
GSE200369
ID:
200200369
2.

Aging aggravates aortic aneurysm and dissection via the miR-1204-MYLK signaling axis

(Submitter supplied) The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. more...
Organism:
Human alphaherpesvirus 2; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis
Type:
Non-coding RNA profiling by array
Platform:
GPL21439
12 Samples
Download data: GPR, XLSX
Series
Accession:
GSE253747
ID:
200253747
3.

Increased pro-inflammatory phenotype of peripheral blood monocytes and monocyte-derived macrophages among patients with excessive ethanol intake

(Submitter supplied) Excessive alcohol consumption adversely affects the immune system and triggers the activation of peripheral blood (PB) monocytes and tissue macrophages, contributing to alcohol- related organ damage. This study aimed to analyze the M1/M2 and inflammatory phenotypes of circulating monocytes and macrophage-derived monocytes (MDMs). This single-center cross- sectional study included 20 excessive alcohol drinkers (EADs) and 22 healthy controls. more...
Organism:
Murid gammaherpesvirus 4; Betapolyomavirus hominis; Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
22 Samples
Download data: GPR, TXT
Series
Accession:
GSE239659
ID:
200239659
4.

Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAs

(Submitter supplied) Congenital human cytomegalovirus (HCMV) infection is the leading infectious cause of birth defects, including neurodevelopmental disorders. HCMV infection mainly targets neural progenitor cells (NPCs) in fetal brains, inducing abnormal differentiation by altering key regulatory pathways. HCMV expresses a series of viral miRNAs during infection, but their roles, particularly in NPCs, are not fully understood. more...
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Non-coding RNA profiling by array
Platform:
GPL32365
10 Samples
Download data: XLS
Series
Accession:
GSE206370
ID:
200206370
5.

Role of the HCMV immediate early proteins in controlling the HCMV transcriptome

(Submitter supplied) Purpose: to investigate the role of the HCMV immediate early genes in controlling the HCMV and cellular transcriptomes
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29977
4 Samples
Download data: BIGWIG
Series
Accession:
GSE171521
ID:
200171521
6.

Role of the HCMV immediate early proteins in controlling the HCMV and cellular epigenomes

(Submitter supplied) Purpose: to investigate the role of the HCMV immediate early proteins in controlling the HCMV and cellular epigneomes during lytic infectioin
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL29977
16 Samples
Download data: BIGWIG
Series
Accession:
GSE171518
ID:
200171518
7.

HCMV epigenome and transcriptome during early lytic infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL29977 GPL24676
25 Samples
Download data: BIGWIG
Series
Accession:
GSE171522
ID:
200171522
8.

HCMV transcriptome during early lytic infection

(Submitter supplied) Purpose: to investigate expression of HCMV and cellular RNAs at early times post-infection in a lytic model
Organism:
Human betaherpesvirus 5; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29977
2 Samples
Download data: BIGWIG
Series
Accession:
GSE171520
ID:
200171520
9.

HCMV epigenome during early lytic infection

(Submitter supplied) Purpose: to investigate occupancy of Pol II and H3K27Ac on the HCMV and cellular genomes at early times post-infection in a lytic model
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL29977
8 Samples
Download data: BIGWIG
Series
Accession:
GSE171512
ID:
200171512
10.

Genome-wide screen reveals UL49 is an essential vPIC subunit that transcribes late Human Cytomegalovirus genes

(Submitter supplied) More than half the world's population is infected with Human Cytomegalovirus (HCMV), increasing risks for the immuno-compromised, and causing significant congenital birth defects. The HCMV genome encodes >170 proteins; many that remain uncharacterised, which restricts development opportunities for new antivirals. In this study, a molecular assay was developed to conduct a genome-wide HCMV screen to identify genes that function during late stages of infection. more...
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32186
17 Samples
Download data: TXT
Series
Accession:
GSE201208
ID:
200201208
11.

MiRNAs array after SH3BP2 silencing in Gastrointestinal stromal tumor cells

(Submitter supplied) Silencing of the adaptor SH3BP2 impairs Gastrointestinal stromal tumors growth through miRNAs We dissected SH3BP2 pathway in Gastrointestinal Stromal Tumor cells (GIST) performing a miRNA array in SH3BP2-silenced GIST cells
Organism:
Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; Betapolyomavirus hominis
Type:
Non-coding RNA profiling by array
Platform:
GPL21599
12 Samples
Download data: TXT, XLSX
Series
Accession:
GSE213777
ID:
200213777
12.

Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections

(Submitter supplied) Primary infection with Human cytomegalovirus (HCMV) results in a persistent lifelong infection due to its ability to establish latent infection. During productive HCMV infection, viral genes are expressed in a coordinated cascade that is characteristic of all herpesviruses and traditionally relies on the dependencies of viral genes on protein synthesis and viral DNA replication. In contrast, the transcriptional landscape associated with HCMV latency is still disputed and poorly understood. more...
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29977
90 Samples
Download data: CSV
Series
Accession:
GSE193467
ID:
200193467
13.

Esrrb Regulates Specific Feed-Forward Loops to Transit from Pluripotency into Early Stages of Differentiation

(Submitter supplied) Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been shown to be crucial for embryonic stem (ES) self-renewal maintenance and cellular differentiation, the role of miRNAs integrated into gene regulatory networks and its dynamic changes during these state transitions remain elusive. more...
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Betapolyomavirus hominis; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; Murid gammaherpesvirus 4; human gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae
Type:
Non-coding RNA profiling by array
Platform:
GPL18658
12 Samples
Download data: TXT
Series
Accession:
GSE57371
ID:
200057371
14.

Downregulation of Neurodevelopmental Gene Expression in iPSC-Derived Cerebral Organoids Upon Infection by Human Cytomegalovirus

(Submitter supplied) We report the application of bulk RNA sequencing on cerebral organoids infected with HCMV TB40eGFP virus or uninfected, within the infected groups the organoids were sorted into 3 distinct populations prior to sequencing based on GFP expression as a proxy for level of infection. These populations have been denoted GFP (+), GFP Inter, GFP (-), for each sorted population 3 organoids of the same line and from the same differentiation were combined to ensure sufficient cell numbers for bulk sequencing analysis.
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL24259
12 Samples
Download data: XLSX
Series
Accession:
GSE193759
ID:
200193759
15.

Epigenetic reprogramming of host and viral genes by Human Cytomegalovirus infection in Kasumi-3 myeloid progenitor cells at early times post-infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
6 related Platforms
79 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE164861
ID:
200164861
16.

Pol2 occupancy of the viral and host genomes in HCMV infected Kasumi-3 cells at 24 hpi

(Submitter supplied) Purpose: to compare Pol2 occupancy of the host genome in HCMV infected and mock infected Kasumi-3 cells at 24 hours post infection and analyze Pol2 occupancy of the viral genome in GFP+ infected cells
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL20301 GPL18573 GPL24958
8 Samples
Download data: BIGWIG
Series
Accession:
GSE164845
ID:
200164845
17.

Pol2 and H3K27Ac and H3K27me3 occupancy of the viral genome in HCMV infected Kasumi-3 cells at early times post infection

(Submitter supplied) Purpose: to compare Pol2 and H3K27Ac and H3K27me3 in HCMV infected Kasumi-3 cells at 4 and 24 hours post infection
Organism:
Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL29601 GPL29602
24 Samples
Download data: BIGWIG
Series
Accession:
GSE164844
ID:
200164844
18.

Comparison of HCMV nascent and steady state transcriptomes expresssed in the Kasumi-3 latency model at early times post-infection

(Submitter supplied) Purpose: to compare newly transcribed and steady-state HCMV RNAs expressed in Kasumi-3 cells at 24 hr post-infection
Organism:
Human betaherpesvirus 5; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL24958
10 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE164843
ID:
200164843
19.

Pol2 and H3K27Ac and H3K27me3 occupancy of the viral and host genomes in HCMV infected Kasumi-3 cells at 24 hpi

(Submitter supplied) Purpose: to compare H3K27Ac and H3K27me3 in HCMV infected and mock infected Kasumi-3 cells at 24 hours post infection and analyze H3K27Ac and H3K27me3 occupancy of the viral genome in GFP+ infected cells
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL20301 GPL29603
21 Samples
Download data: BIGWIG
Series
Accession:
GSE164842
ID:
200164842
20.

Chromatin accessibilty analysis of HCMV infected and mock-infected Kasumi-3 cells at 24 hours post infection

(Submitter supplied) Purpose: to compare host gene expression in HCMV infected and mock infected Kasumi-3 cells at 24 hours post infection and analyze viral chromatin accessibility
Organism:
Homo sapiens; Human betaherpesvirus 5
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18573 GPL24958
6 Samples
Download data: BIGWIG
Series
Accession:
GSE164841
ID:
200164841
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