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Items: 1 to 20 of 5094

1.

Candida albicans PPG1, a serine/threonine phosphatase, plays a vital role in central carbon metabolisms under filament-inducing conditions: A multi-omics approach

(Submitter supplied) Candida albicansis the leading cause of life-threatening bloodstream candidiasis, especially among immunocompromised patients. The reversible morphological transition from yeast to hyphal filaments in response to host environmental cues facilitatesC.albicanstissue invasion, immune evasion, and dissemination. Hence, it is widely considered that filamentation represents one of the major virulence properties inC.albicans. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33213
8 Samples
Download data: TXT
Series
Accession:
GSE263609
ID:
200263609
2.

A highly conserved tRNA modification contributes to C. albicans filamentation and virulence

(Submitter supplied) tRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad range of phenotypes in baker’s yeast. Very little is known about the function of tRNA modifications in host-pathogen interactions, where rapidly changing environments and stresses require fast adaptations. more...
Organism:
Candida albicans
Type:
Other
Platform:
GPL22403
12 Samples
Download data: TXT
Series
Accession:
GSE199421
ID:
200199421
3.

Peptide YY: a Paneth cell antimicrobial peptide that maintains Candida gut commensalism.

(Submitter supplied) The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility, while some regulate the microbiota. We report peptide YY (PYY1-36), but not endocrine PYY3-36, is an antimicrobial peptide (AMP) expressed by gut epithelial Paneth Cells (PC). PC-PYY has limited antibacterial activity, but shows selective activity against virulent hyphal, but not yeast forms, of Candida albicans. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28323
12 Samples
Download data: CSV
Series
Accession:
GSE229566
ID:
200229566
4.

The Hxk1 protein of Candida albicans influences gene expression of both metabolic and virulence related genes

(Submitter supplied) The Hxk1 protein of Candida albicans is a moonlighting protein with a wide variety of functions. It phosphorylates N-acetylglucosamine (GlcNAc) which is necessary for different purposes in the cell including energy and chitin production. Further, this protein is a regulator for morphogenesis independent of its function during GlcNAc catabolism.To identify the regulatory role of Hxk1 and putative downstream regulator Hxk2, we performed CUT&RUN experiments for GFP-tagged Hxk1 strains and GFP-tagged Hxk2 strains.
Organism:
Candida albicans
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL22403
12 Samples
Download data: NARROWPEAK
Series
Accession:
GSE254730
ID:
200254730
5.

Manganese homeostasis modulates fungal virulence and stress tolerance in Candida albicans

(Submitter supplied) As transition metal availability is very limited inside the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned into iron, copper and zinc acquisition mechanisms and their importance in fungal fitness, less was done regarding either the role of Mn in infectious processes or the cellular mechanism by which fungal cells achieve their Mn-homeostasis. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28323
12 Samples
Download data: TXT
Series
Accession:
GSE245114
ID:
200245114
6.

Candida albicans interaction with intestinal epithelial cells

(Submitter supplied) To characterize the interaction of Candida albicans with intestinal epithelial cells (C2BBe1) from early fungal adhesion to invasion (up to 6 h) and the late translocation and damage phase (12 -24 h), we conducted dual RNA-sequencing of C. albicans-infected C2BBe1 cells over a 24 h time course, with sampling at 0 h, 45 min, 3 h, 6 h, 12 h, and 24 h.
Organism:
Homo sapiens; Candida albicans
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18448 GPL20301
51 Samples
Download data: XLS
Series
Accession:
GSE237496
ID:
200237496
7.

The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain-dependent

(Submitter supplied) Clinical isolates of the human fungal pathogen Candida albicans show significant variation in their ability to undergo in vitro filamentation. In this study, we show that Nrg1, a key repressor of filamentation and filament specific gene expression in standard laboratory strain, has strain dependent functions, especially during infection.
Organism:
Candida albicans
Type:
Other
Platform:
GPL34110
44 Samples
Download data: RCC, XLSX
Series
Accession:
GSE253732
ID:
200253732
8.

An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts

(Submitter supplied) Yeasts are naturally diverse, genetically tractable, and easy to grow such that researchers can investigate any number of genotypes, environments, or interactions thereof. However, studies of yeast transcriptomes have been limited by the processing capabilities of traditional RNA sequencing techniques. Here we optimize a powerful, high-throughput single-cell RNA sequencing (scRNAseq) platform, SPLiT-seq (Split Pool Ligation-based Transcriptome sequencing), for yeasts and apply it to 43,388 cells of multiple species and ploidies. more...
Organism:
Saccharomyces cerevisiae; Candida albicans
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL26171 GPL34036
7 Samples
Download data: MTX, TSV
Series
Accession:
GSE251966
ID:
200251966
9.

Whole genome mRNA expression profiling during Candida albicans growth in complete human serum and butanol

(Submitter supplied) In order to get an insight into the complex interplay of mRNAs during the growth in complete human serum supplemented with butanol, the total RNA population of Candida albiacns NCCPF 400034 extracted at 20, 45, and 120 minutes was sequenced by Next Generation sequencing techniques. The control RNA was extracted from Candida cells placed in YPD medium for 18 hrs at 37 ° C and was also sequenced using the next generation sequenicng technique.
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL15149 GPL28323
8 Samples
Download data: XLSX
Series
Accession:
GSE168874
ID:
200168874
10.

Whole genome mRNA expression profiling during Candida albicans growth in complete human serum

(Submitter supplied) In order to get an insight into the complex interplay of mRNAs during the growth in complete human serum, the mRNA polulation of Candida albiacns NCCPF 400034 taken at 0, 20, 45, and 120 minutes was extracted and sequenced by Next Generation sequencing techniques.
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL15149 GPL15645
8 Samples
Download data: XLSX
Series
Accession:
GSE168619
ID:
200168619
11.

Identification of genes regulated by the transcription factor RFX1 (CR_06110C) in the yeast Candida albicans

(Submitter supplied) The regulatory factor X (RFX) gene family comprises a functionally diverse group of transcription factors characterized by a highly conserved and unique winged-helix DNA binding domain. The RFX proteins control a variety of processes ranging from genome integrity and cell cycle in model yeasts to immune functions and tissue differentiation in higher eukaryotes. The yeast Candida albicans encodes two RFX homologs, one of which (CR_06110C, termed RFX1) remains uncharacterized. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28323
6 Samples
Download data: TXT
Series
Accession:
GSE249927
ID:
200249927
12.

CTR9 affects virulence of Candida albicans by regulating methionine metabolism

(Submitter supplied) Project Abstract : Paf1C is a general transcription regulator and is associated with various human diseases. One of its subunits, CTR9, is known as a structurally and functionally core component of Paf1C. While its role in higher eukaryotes have been researched, the association between the core component and human fungal pathogen is not fully understood yet. During pre-infection process, Candida albicans adheres to the surface of hosts and sufficiently grows as the circular form. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19036
12 Samples
Download data: BW
Series
Accession:
GSE244665
ID:
200244665
13.

Filamentation and Biofilm Formation are Regulated by the Phase-Separation Capacity of Network Transcription Factors in Candida albicans

(Submitter supplied) The ability of the fungus Candida albicans to filament and form biofilms contributes to its burden as a leading cause of hospital-acquired infections. Biofilm development involves an interconnected transcriptional regulatory network (TRN) consisting of nine transcription factors (TFs) that bind both to their own regulatory regions and to those of the other network TFs. Here, we show that seven of the nine TFs in the C. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28323
12 Samples
Download data: CSV, TXT
Series
Accession:
GSE245897
ID:
200245897
14.

Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome

(Submitter supplied) In dinoflagellates, the most unique and divergent nuclear organization among the known diversity of eukaryotes has evolved. The list of highly unusual features of dinoflagellate nuclei and genomes is long -- permanently condensed liquid crystalline chromosomes, in which histones are not the main packaging component, genes organized as very long unidirectional gene arrays, general absence of transcriptional regulation, high abundance of the otherwise very rare DNA modification 5-hydroxymethyluracil (5-hmU), and many others. more...
Organism:
Homo sapiens; Bigelowiella natans; Breviolum minutum; Saccharomyces cerevisiae; Candida albicans
Type:
Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other
4 related Platforms
34 Samples
Download data: BEDGRAPH, BIGWIG
Series
Accession:
GSE241969
ID:
200241969
15.

Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA

(Submitter supplied) Fungal pathogens threaten ecosystems and human health. Understanding the molecular basis of their virulence is key to develop new treatment strategies. Here, we characterize NCS2*, a point mutation identified in a clinical baker's yeast isolate. Ncs2 is essential for 2-thiolation of tRNA and the NCS2* mutation leads to increased thiolation at body temperature. NCS2* yeast exhibits enhanced fitness when grown at elevated temperatures or when exposed to oxidative stress, inhibition of nutrient signalling, and cell-wall stress. more...
Organism:
Candida albicans
Type:
Other
Platform:
GPL22403
12 Samples
Download data: TXT
Series
Accession:
GSE199422
ID:
200199422
16.

Variation in transcription regulator expression underlies differences in white-opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates.

(Submitter supplied) Expression of 68 genes was tracked across different C. albicans strains and enviornmenal conditions using a custom 72 probe Nanostring library
Organism:
Candida albicans
Type:
Expression profiling by array
Platform:
GPL33714
76 Samples
Download data: RCC, XLSX
Series
Accession:
GSE241766
ID:
200241766
17.

Genome-wide Translational Response of Candida albicans to Fluconazole Treatment

(Submitter supplied) Azoles are commonly used for the treatment of fungal infections and the ability of human fungal pathogens to rapidly respond to azole treatment is critical for the development of antifungal resistance. While the role of genetic mutations, chromosomal rearrangements and transcriptional mechanisms in azole resistance has been well-characterized, very little is known about post-transcriptional and translation mechanisms that drive this process. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27827
16 Samples
Download data: TSV
Series
Accession:
GSE227590
ID:
200227590
18.

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral commensalism

(Submitter supplied) Candida albicans is a diploid human fungal pathogen that displays significant genomic and phenotypic heterogeneity over a range of virulence traits and in the context of a variety of environmental niches. Here, we show that the effects of Rob1 on biofilm and filamentation virulence traits is dependent on both the specific environmental condition and the clinical strain of C. albicans. The C. albicans reference strain SC5314 is a ROB1 heterozygote with two alleles that differ by a single nucleotide polymorphism at position 946 resulting in a serine or proline containing isoform. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9133
12 Samples
Download data: TXT
Series
Accession:
GSE238051
ID:
200238051
19.

Inferring gene regulatory networks via transcriptional profiles as associated dynamical attractors

(Submitter supplied) Genetic regulatory networks (GRNs) regulate the flow of genetic information from the genome to expressed messenger RNAs (mRNAs) and thus are critical to controlling the phenotypic characteristics of cells. Numerous methods exist for profiling mRNA transcript levels and identifying protein-DNA binding interactions at the genome-wide scale. These enable researchers to determine the structure and output of transcriptional regulatory networks, but uncovering the complete structure and regulatory logic of GRNs remains a challenge. more...
Organism:
Candida albicans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24129
51 Samples
Download data: TXT
Series
Accession:
GSE217461
ID:
200217461
20.

Inferring gene regulatory networks via transcriptional profiles as associated dynamical attractors

(Submitter supplied) Genetic regulatory networks (GRNs) regulate the flow of genetic information from the genome to expressed messenger RNAs (mRNAs) and thus are critical to controlling the phenotypic characteristics of cells. Numerous methods exist for profiling mRNA transcript levels and identifying protein-DNA binding interactions at the genome-wide scale. These enable researchers to determine the structure and output of transcriptional regulatory networks, but uncovering the complete structure and regulatory logic of GRNs remains a challenge. more...
Organism:
Candida albicans
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL24129
12 Samples
Download data: BW
Series
Accession:
GSE217383
ID:
200217383
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