U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 285

1.

Two distinct Trypanosoma eIF4F complexes co-exist, bind different mRNAs and are regulated during nutritional stress

(Submitter supplied) Many eIF4F subunits and PABP paralogues are found in trypanosomes: six eIF4E, five eIF4G, one eIF4A and two PABPs. They are expressed simultaneously and assemble into different complexes, contrasting the situation in metazoans that use distinct complexes in different cell types or developmental stages. Each eIF4F complex has its own proteins, mRNAs and, consequently, a distinct function. We set out to study the function and regulation of the two major eIF4F complexes of Trypanosoma cruzi. more...
Organism:
Trypanosoma cruzi
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL34379
65 Samples
Download data: TXT
Series
Accession:
GSE263777
ID:
200263777
2.

Trypanosoma cruzi conserved proteome microarray

(Submitter supplied) Antibody recognition of Trypanosoma cruzi conserved proteins was assessed by evaluating pools of patient IgG samples on microarrays of 400,000 peptides covering these proteins as 15-mers with an overlap of 13 amino acids.
Organism:
Trypanosoma cruzi; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL33498
3 Samples
Download data: TXT
Series
Accession:
GSE235074
ID:
200235074
3.

Experimental and Bioinformatic upgrade for genome-wide mapping of nucleosomes in Trypanosoma cruzi

(Submitter supplied) We adapted the widely used digestion of chromatin with micrococcal nuclease (MNase) followed by deep sequencing to the parasite Trypanosoma cruzi, which presents numerous singularities. In this work, we use the hybrid CL Brener strain carrying two set of chromosomes from two substantially different parental strains. The hybrid strain CL Brener is composed of the Esmeraldo-like and non Esmeraldo-like haplotypes. more...
Organism:
Trypanosoma cruzi
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL30239
4 Samples
Download data: BW, TXT
Series
Accession:
GSE176341
ID:
200176341
4.

Trypanosoma cruzi CLB vs Trypanosoma rangeli and Trypanosoma conorhini

(Submitter supplied) Comparative genomic analysis of T. cruzi CLB vs Trypanosoma rangeli (strains SC, Choachí, C23, H14, R1625 and PIT10) and Trypanosoma conorhini
Organism:
Trypanosoma cruzi; Trypanosoma rangeli; Trypanosoma conorhini
Type:
Genome variation profiling by array
Platform:
GPL32014
16 Samples
Download data: TXT, XLSX
Series
Accession:
GSE229354
ID:
200229354
5.

aCGH Trypanosoma cruzi G vs D11.

(Submitter supplied) Comparative genomic analysis of Trypanosoma cruzi G with Trypanosoma cruzi D11.
Organism:
Trypanosoma cruzi
Type:
Genome variation profiling by array
Platform:
GPL32014
4 Samples
Download data: TXT
Series
Accession:
GSE197870
ID:
200197870
6.

Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector

(Submitter supplied) Using the Deep Seq transcriptome sequencing we characterized the heme induced transcriptome of epimastigotes and determined that most of the upregulated genes were related to glucose metabolism inside the glycosomes.
Organism:
Trypanosoma cruzi
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27740
5 Samples
Download data: TXT
Series
Accession:
GSE172452
ID:
200172452
7.

Differential transcriptome of human dendritic cells at first contact with Trypanosoma cruzi reveals response to virus as a central unexplored pathway

(Submitter supplied) Chagas disease is a notorious public health problem worldwide. However, the pathology is still poorly understood in humans and dendritic cells (DCs) have a determinant role during infection that could help to understand what happens with immune response during the first contact. Here we performed a transcriptomic analysis of the interaction between DCs from three human donors and the infective forms of T. more...
Organism:
Trypanosoma cruzi; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL29219
12 Samples
Download data: XLS
Series
Accession:
GSE158986
ID:
200158986
8.

Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix

(Submitter supplied) Adhesion of T. cruzi trypomastigotes to components of the extracellular matrix (ECM) is an important step in mammalian host cell invasion. We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes are incubated with components of the ECM. In this work, we used chromatin immunoprecipitation (ChIP) with an anti-nitro-tyrosine antibody followed by mass spectrometry to identify nitrated DNA binding proteins in T. more...
Organism:
Trypanosoma cruzi
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL27740
4 Samples
Download data: BEDGRAPH
Series
Accession:
GSE140245
ID:
200140245
9.

Ribonomic identification of mRNAs associated with RNA binding proteins TcRBP7 and TcRBP40 from Trypanosoma cruzi

(Submitter supplied) TcRBP7 and TcRBP40 proteins are adjacent paralogs in T. cruzi with a conserved RRM structure and similar protein localization at specific foci at the posterior region. We identified their targets in order to compare their function, infering about the evolutionary implication of regulatory proteins duplication. Surprisingly, the mRNA targets co-immunoprecipitated with each RBP were distinct, pointing to a subfunctionalization outcome. more...
Organism:
Trypanosoma cruzi
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23054
9 Samples
Download data: TXT
Series
Accession:
GSE106934
ID:
200106934
10.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rhodotorula; Bos taurus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Quercus alba; Trypanosoma cruzi; Bothrops moojeni; Pachymenia carnosa; Gossypium hirsutum; Pandalus borealis; Oncorhynchus nerka; Homo sapiens; Sus scrofa domesticus; Gallus gallus; Oryctolagus cuniculus; Mus musculus; Human immunodeficiency virus 1; unidentified; Megathura crenulata
Type:
Protein profiling by protein array
Platforms:
GPL23565 GPL23566
55 Samples
Download data: GPR
Series
Accession:
GSE100438
ID:
200100438
11.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies VII

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Trypanosoma cruzi; Gallus gallus; Pachymenia carnosa; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Ovis aries; Oryctolagus cuniculus; Megathura crenulata; Frangula alnus; Quercus alba; Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ceratonia siliqua; Bothrops moojeni; Senegalia senegal; Dermestes lardarius
Type:
Protein profiling by protein array
Platform:
GPL23566
7 Samples
Download data: GPR, TXT
Series
Accession:
GSE100310
ID:
200100310
12.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies VI

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Quercus alba; Oryctolagus cuniculus; Megathura crenulata; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Trypanosoma cruzi; Gallus gallus; Bothrops moojeni; Pachymenia carnosa; Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius
Type:
Protein profiling by protein array
Platform:
GPL23566
7 Samples
Download data: GPR, TXT
Series
Accession:
GSE100309
ID:
200100309
13.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies V

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Rhodotorula; Trypanosoma cruzi; Gallus gallus; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Pachymenia carnosa; Homo sapiens; Bos taurus; Quercus alba; Gossypium hirsutum; Oryctolagus cuniculus; Megathura crenulata; Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius
Type:
Protein profiling by protein array
Platform:
GPL23566
7 Samples
Download data: GPR, TXT
Series
Accession:
GSE100308
ID:
200100308
14.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies IV

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Quercus alba; Gossypium hirsutum; Pandalus borealis; Oncorhynchus nerka; Homo sapiens; Trypanosoma cruzi; Bos taurus; Rhodotorula; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Senegalia senegal; Pachymenia carnosa; Dermestes lardarius; Gallus gallus; Sus scrofa domesticus; Ovis aries; Oryctolagus cuniculus; Ceratonia siliqua; Megathura crenulata; Frangula alnus
Type:
Protein profiling by protein array
Platform:
GPL23566
7 Samples
Download data: GPR, TXT
Series
Accession:
GSE100307
ID:
200100307
15.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies III

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Trypanosoma cruzi; Gallus gallus; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Pachymenia carnosa; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Quercus alba; Oryctolagus cuniculus; Megathura crenulata; Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius
Type:
Protein profiling by protein array
Platform:
GPL23566
7 Samples
Download data: GPR, TXT
Series
Accession:
GSE99874
ID:
200099874
16.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies II

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Quercus alba; Gossypium hirsutum; Oncorhynchus nerka; Homo sapiens; Bos taurus; Rhodotorula; Trypanosoma cruzi; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Senegalia senegal; Pachymenia carnosa; Pandalus borealis; Gallus gallus; Sus scrofa domesticus; Ovis aries; Oryctolagus cuniculus; Ceratonia siliqua; Megathura crenulata; Frangula alnus; Dermestes lardarius
Type:
Protein profiling by protein array
Platform:
GPL23566
14 Samples
Download data: GPR, TXT
Series
Accession:
GSE99873
ID:
200099873
17.

Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies I

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...
Organism:
Rhodotorula; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Ceratonia siliqua; Bothrops moojeni; Senegalia senegal; Pachymenia carnosa; Dermestes lardarius; Trypanosoma cruzi; Quercus alba; Gossypium hirsutum; Pandalus borealis; Oncorhynchus nerka; Homo sapiens; Sus scrofa domesticus; Gallus gallus; Ovis aries; Oryctolagus cuniculus; unidentified; Megathura crenulata; Frangula alnus
Type:
Protein profiling by protein array
Platform:
GPL23565
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE99872
ID:
200099872
18.

Trypanosoma cruzi mini-exon based mRNA amplification technique

(Submitter supplied) We have developed a method of mRNA amplification based on T7 polymerase, where T7 promoter is attached to a oligonucleotide containing the mini-exon sequence, which will hybridize with cDNA molecules containing the anti-ME sequence
Organism:
Homo sapiens; Trypanosoma cruzi
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL23054 GPL11154
46 Samples
Download data: TXT
Series
Accession:
GSE94766
ID:
200094766
19.

Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to profile anti-glycan immune responses to whole-cell vaccines: GVAX Pancreas, K562-GM and H1299. The aim was to indentify anti-glycan antibody responses relevent to patient clinical outcomes Results: Immune responses to non-human antigens bovine fetuin and alpha-Gal antigens were identified induced by GVAX Pancreas. The magnitude of these responses inversely correlate with patient survival. more...
Organism:
Trypanosoma cruzi; Gallus gallus; Bothrops moojeni; Pachymenia carnosa; Pandalus borealis; Oncorhynchus nerka; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Quercus alba; Oryctolagus cuniculus; Megathura crenulata; Gossypium hirsutum; Homo sapiens; Bos taurus; Mus musculus; Human immunodeficiency virus 1
Type:
Other
Platform:
GPL21991
168 Samples
Download data: GPR, TXT
Series
Accession:
GSE83087
ID:
200083087
20.

A Simple, Inexpensive Strategy for Predicting Potential Beneficial Clinical Responses on Prostate Cancer Vaccine Therapy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Trypanosoma cruzi; Gallus gallus; Bothrops moojeni; Pachymenia carnosa; Quercus alba; Megathura crenulata; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Mus musculus; Pandalus borealis; Oncorhynchus nerka; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius
Type:
Other
Platforms:
GPL20117 GPL20116
331 Samples
Download data
Series
Accession:
GSE68405
ID:
200068405
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid5693[Organism:noexp]|query=1|qty=72|blobid=MCID_6626cf7f4c13c13a068fc7ec|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center