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Items: 1 to 20 of 482

1.

Comparative transcriptome analysis reveals metabolic differences between planktonic and biofilm of Actinobacillus pleuropneumoniae.

(Submitter supplied) To reveal the transcriptional profiles of Actinobacillus pleuropneumoniae under biofilm and planktonic growth, we established a biofilm-forming culture method and constructed a mutant strain Δpga with defect in biofilm formation. Wild-type and Δpga mutant strains of Actinobacillus pleuropneumoniae strain 4074 were cultured in bottles with shaking for planktonic (WT_PK) and in microplates in static status for biofilm (WT_BF, Δpga), respectively. more...
Organism:
Actinobacillus pleuropneumoniae serovar 1 str. 4074
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32988
9 Samples
Download data: TXT
Series
Accession:
GSE221940
ID:
200221940
2.

Actinobacillus pleuropneumoniae encodes multiple phase-variable DNA methyltransferases that control distinct phasevarions

(Submitter supplied) Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (phase-variable regulons). Phasevarions result from variable expression of cytoplasmic DNA methyltransferases. Variable expression results in genome-wide methylation differences within a bacterial population, leading to altered expression of multiple genes via epigenetic mechanisms. more...
Organism:
Escherichia coli; Actinobacillus pleuropneumoniae
Type:
Other
Platforms:
GPL33074 GPL33073
16 Samples
Download data: RDS
Series
Accession:
GSE224057
ID:
200224057
3.

CpxAR of Actinobacillus pleuropneumoniae Contributes to Heat Stress Response by Repressing Expression of Type IV Pilus Gene apfA

(Submitter supplied) Acute pleuropneumonia in swine, caused by Actinobacillus pleuropneumoniae (APP), is characterized by a high and sustained fever. Fever creates an adverse environment for many bacteria leading to reduced bacterial proliferation; however, most pathogenic bacteria can tolerate higher temperatures. CpxAR is a two-component regulation system, ubiquitous among Gram-negative bacteria, which senses and responds to envelope alterations that are mostly associated with protein misfolding in the periplasm. more...
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30447
6 Samples
Download data: TXT
Series
Accession:
GSE214078
ID:
200214078
4.

Effects of two-component system NarQ/P deletion on gene expression of Actinobacillus pleuropneumoniae in nitrate-rich anaerobic growth

(Submitter supplied) Nitrate metabolism is an adaptation mechanism used by many bacteria for survival under anaerobic environments. As a by-product of inflammation, nitrate is used by the intestinal bacterial pathogens to enable gut infection. However, the responses of bacterial respiratory pathogens to nitrate are less well understood. Actinobacillus pleuropneumoniae is an important bacterial respiratory pathogen of swine. more...
Organism:
Actinobacillus pleuropneumoniae serovar 1 str. 4074
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32420
18 Samples
Download data: XLSX
Series
Accession:
GSE207497
ID:
200207497
5.

Genome-wide screening and characterization of Actinobacillus pleuropneumoniae and its ciprofloxacin-resistant mutants

(Submitter supplied) Understanding constraints which shape antibiotic resistance is key for predicting and controlling drug resistance. Here, we performed high-throughput laboratory evolution of Actinobacillus pleuropneumoniae and its ciprofloxacin resistance-inducing derivatives.This study aims to explore the mechanism of acquired ciprofloxacin resistance in Actinobacillus pleuropneumoniae.
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30447
6 Samples
Download data: FASTA, GFF3, TXT
Series
Accession:
GSE181030
ID:
200181030
6.

Identification of the genes regulated by the two-component system response regulator NarP of Actinobacillus pleuropneumoniae by DNA-affinity-purified (DAP) sequencing

(Submitter supplied) Identification of the direct target genes of a response regulators (RRs) of a bacterial two-component system (TCS) is critical to understand the roles of the TCS in bacterial environmental adaption and pathogenesis. A. pleuropneumoniae is an important respiratory bacterial pathogen causing great economic losses to swine industry worldwide. The triggering signal(s) and targets of the RR NarP belonging to the TCS NarQ/NarP of A. more...
Organism:
Actinobacillus pleuropneumoniae
Type:
Other
Platform:
GPL24322
2 Samples
Download data: BED
Series
Accession:
GSE107526
ID:
200107526
7.

A transcriptome map of Actinobacillus pleuropneumoniae at single-nucleotide resolution using RNA-seq

(Submitter supplied) We used the RNA-seq technology to do a genome-wide transcriptional analysis of A. pleuropneumoniae strain JL03 and investigated the transcriptome structure at a single-nucleotide resolution.The RNA-Seq based transcriptome map validated annotated genes and corrected annotations of open reading frames in the genome, and led to the identification of many functional elements (e.g. regions encoding novel proteins, non-coding sRNAs and operon structures).
Organism:
Actinobacillus pleuropneumoniae serovar 3 str. JL03
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20603
1 Sample
Download data: BED
Series
Accession:
GSE70153
ID:
200070153
8.

Expression data of Actinobacillus pleuropneumoniae 4074 in response to serum, epinephrine, norepinephrine and dopamine

(Submitter supplied) Bacteria can actively respond to host stress hormones (catecholamines), thereby regulate their growth, metabolism, virulence and other behaviors. This phenomenon provides new explanations of the fact that stress can influence the occurrence and development of infectious disease. Actinobacillus pleuropneumoniae is an important swine respiratory pathogen which has caused great economic losses worldwide. more...
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 1 str. 4074
Type:
Expression profiling by array
Platform:
GPL8394
15 Samples
Download data: TXT
Series
Accession:
GSE61054
ID:
200061054
9.

Expression profiles of Actinobacillus pleuropneumoniae 4074 and the qseB/qseC gene-deleted mutant

(Submitter supplied) To determine the role of Actinobacillus pleuropneumoniae two-component system QseBQseC, we constructed a qseBqseC gene-deleted mutant ΔqseBΔqseC based on the wild type A. pleuropneumoniae 4074. The transcriptional profiles were compared between the A. pleuropneumoniae ΔqseBΔqseC and its parental strain under the normal growth condition using microarray. A total of 44 genes were found differentially expressed (DE) compared to the wild type strain. more...
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by array
Platform:
GPL9691
2 Samples
Download data: TXT
Series
Accession:
GSE49812
ID:
200049812
10.

Expression data of Actinobacillus pleuropneumoniae 4074 under aerobic and anaerobic environment

(Submitter supplied) Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry worldwide. Oxygen deprivation is a stress that A. pleuropneumoniae will encounter during both early infection and the later, persistent stage. To understand modulation of A. pleuropneumoniae gene expression in response to the stress caused by anaerobic conditions, gene expression profiles under anaerobic and aerobic conditions were compared in this study. more...
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 1 str. 4074
Type:
Expression profiling by array
Platform:
GPL9691
3 Samples
Download data: TXT
Series
Accession:
GSE39801
ID:
200039801
11.

Transcriptome of A. pleuropneumoniae biofilms cultured under different growth conditions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Actinobacillus pleuropneumoniae serovar 5b str. L20; Actinobacillus pleuropneumoniae
Type:
Expression profiling by array
Platform:
GPL6658
16 Samples
Download data: MEV
Series
Accession:
GSE43824
ID:
200043824
12.

Characterization of the transcriptomes Actinobacillus pleuropneumoniae drip flow biofilm dripflow biofilm

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae dripbiofilm biofilms was compared to the transcriptome of effluent cells
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20
Type:
Expression profiling by array
Platform:
GPL6658
4 Samples
Download data: MEV
Series
Accession:
GSE43823
ID:
200043823
13.

Comparison between the transcriptomes of 4h static biofilm and a 6h static biofilm of Actinobacillus pleuropneumoniae

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae 4h static biofilms was compared to the transcriptome of 6h static biofilm
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20
Type:
Expression profiling by array
Platform:
GPL6658
4 Samples
Download data: MEV
Series
Accession:
GSE43822
ID:
200043822
14.

Transcriptome of 6h static biofilm Actinobacillus pleuropneumoniae

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20
Type:
Expression profiling by array
Platform:
GPL6658
4 Samples
Download data: MEV
Series
Accession:
GSE43821
ID:
200043821
15.

Transcriptome of 4h static biofilm Actinobacillus pleuropneumoniae

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20
Type:
Expression profiling by array
Platform:
GPL6658
4 Samples
Download data: MEV
Series
Accession:
GSE43820
ID:
200043820
16.

Genome wide transcriptional portrait of Actinobacillus pleuropneumoniae during invasive disease reveals new strategies for survival and persistence in the host

(Submitter supplied) The transcriptional profile of the porcine lung pathogen, Actinobacillus pleuropneumoniae, was monitored during the acute phase of infection in its natural host. Bacterial expression profiles of A. pleuropneumoniae isolated from lung lesions of 25 infected pigs were compared in samples taken 6, 12, 24 and 48 hours post infection.
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by array
Platform:
GPL11003
75 Samples
Download data: TXT, XYS
Series
Accession:
GSE33999
ID:
200033999
17.

Expression data of Actinobacillus pleuropneumoniae 4074 in response to epinephrine and norepinephrine

(Submitter supplied) Bacteria can use host hormones as environment cue to modulate their pathogenic processes, which was discovered to play essential role in disease development. Actinobacillus pleuropneumoniae is one of the most important porcine respiratory pathogens causing great economic losses in the pig industry worldwide. Stress factors were found to contribute to the outcome of A. pleuropneumoniae infection. To test whether A. more...
Organism:
Actinobacillus pleuropneumoniae serovar 1 str. 4074; Actinobacillus pleuropneumoniae
Type:
Expression profiling by array
Platform:
GPL9691
6 Samples
Download data: TXT
Series
Accession:
GSE25516
ID:
200025516
18.

Expression data of Actinobacillus pleuropneumoniae 4074, the ΔluxS mutant and AI-2 supplemented ΔluxS mutant

(Submitter supplied) LuxS is an enzyme involved in the activated methyl cycle. The by-product of this cycle, autoinducer 2 (AI-2), could be an important quorum sensing signal. LuxS was conserved and regulated many behaviors in different bacteria, but in most species, whether the regulations are related to AI-2 mediated quorum sensing is still unknown. In our previous study, Actinobacillus pleuropneumoniae, the etiologic agent of porcine contagious pleuropneumonia, was found to possess the functional LuxS affecting biofilm formation and virulence. more...
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by array
Platform:
GPL9691
32 Samples
Download data: TXT
Series
Accession:
GSE21300
ID:
200021300
19.

Expression data of Actinobacillus pleuropneumoniae 4074 and the ΔluxS mutant of Actinobacillus pleuropneumoniae 4074

(Submitter supplied) LuxS is an enzyme involved in the activated methyl cycle and the by-product autoinducer 2 (AI-2) was a quorum sensing signal in some species. In our previous study, the functional LuxS in AI-2 production was verified in the porcine respiratory pathogen Actinobacillus pleuropneumoniae. Enhanced biofilm formation and reduced virulence were observed in the luxS mutant. To comprehensively understand the luxS function, in this study, the transcriptional profiles were compared between the A. more...
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by array
Platform:
GPL9691
16 Samples
Download data: TXT
Series
Accession:
GSE19056
ID:
200019056
20.

Expression analysis of 6 serotypes of Actinobacillus pleuropneumonia during iron deprivation

(Submitter supplied) Investigation of whole genome changes in six serotypes of Actinobacillus pleuropneumoniae in control cultures compared to bacteria grown in media containg the iron chelator 2,2'-dipyridyl.
Organism:
Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 7; Actinobacillus pleuropneumoniae serovar 2 str. 4226; Actinobacillus pleuropneumoniae serovar 6; Actinobacillus pleuropneumoniae serovar 3; Actinobacillus pleuropneumoniae serovar 5; Actinobacillus pleuropneumoniae serovar 1 str. 4074
Type:
Expression profiling by array
Platform:
GPL11003
48 Samples
Download data: XYS
Series
Accession:
GSE24470
ID:
200024470
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