GEO DataSets

(Submitter supplied) Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (phase-variable regulons). Phasevarions result from variable expression of cytoplasmic DNA methyltransferases. Variable expression results in genome-wide methylation differences within a bacterial population, leading to altered expression of multiple genes via epigenetic mechanisms. more...

Organism:

Escherichia coli; Actinobacillus pleuropneumoniae

Type:

Other

Platforms:

GPL33073 GPL33074

16 Samples

Download data: RDS

(Submitter supplied) Acute pleuropneumonia in swine, caused by Actinobacillus pleuropneumoniae (APP), is characterized by a high and sustained fever. Fever creates an adverse environment for many bacteria leading to reduced bacterial proliferation; however, most pathogenic bacteria can tolerate higher temperatures. CpxAR is a two-component regulation system, ubiquitous among Gram-negative bacteria, which senses and responds to envelope alterations that are mostly associated with protein misfolding in the periplasm. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30447

6 Samples

Download data: TXT

(Submitter supplied) Understanding constraints which shape antibiotic resistance is key for predicting and controlling drug resistance. Here, we performed high-throughput laboratory evolution of Actinobacillus pleuropneumoniae and its ciprofloxacin resistance-inducing derivatives.This study aims to explore the mechanism of acquired ciprofloxacin resistance in Actinobacillus pleuropneumoniae.

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30447

6 Samples

Download data: FASTA, GFF3, TXT

(Submitter supplied) Identification of the direct target genes of a response regulators (RRs) of a bacterial two-component system (TCS) is critical to understand the roles of the TCS in bacterial environmental adaption and pathogenesis. A. pleuropneumoniae is an important respiratory bacterial pathogen causing great economic losses to swine industry worldwide. The triggering signal(s) and targets of the RR NarP belonging to the TCS NarQ/NarP of A. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Other

Platform:

GPL24322

2 Samples

Download data: BED

(Submitter supplied) Bacteria can actively respond to host stress hormones (catecholamines), thereby regulate their growth, metabolism, virulence and other behaviors. This phenomenon provides new explanations of the fact that stress can influence the occurrence and development of infectious disease. Actinobacillus pleuropneumoniae is an important swine respiratory pathogen which has caused great economic losses worldwide. more...

Organism:

Actinobacillus pleuropneumoniae serovar 1 str. 4074; Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL8394

15 Samples

Download data: TXT

(Submitter supplied) To determine the role of Actinobacillus pleuropneumoniae two-component system QseBQseC, we constructed a qseBqseC gene-deleted mutant ΔqseBΔqseC based on the wild type A. pleuropneumoniae 4074. The transcriptional profiles were compared between the A. pleuropneumoniae ΔqseBΔqseC and its parental strain under the normal growth condition using microarray. A total of 44 genes were found differentially expressed (DE) compared to the wild type strain. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL9691

2 Samples

Download data: TXT

(Submitter supplied) Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry worldwide. Oxygen deprivation is a stress that A. pleuropneumoniae will encounter during both early infection and the later, persistent stage. To understand modulation of A. pleuropneumoniae gene expression in response to the stress caused by anaerobic conditions, gene expression profiles under anaerobic and aerobic conditions were compared in this study. more...

Organism:

Actinobacillus pleuropneumoniae serovar 1 str. 4074; Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL9691

3 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Actinobacillus pleuropneumoniae serovar 5b str. L20; Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL6658

16 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae dripbiofilm biofilms was compared to the transcriptome of effluent cells

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae 4h static biofilms was compared to the transcriptome of 6h static biofilm

Organism:

Actinobacillus pleuropneumoniae serovar 5b str. L20; Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria

Organism:

Actinobacillus pleuropneumoniae serovar 5b str. L20; Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL6658

4 Samples

Download data: MEV

(Submitter supplied) The transcriptional profile of the porcine lung pathogen, Actinobacillus pleuropneumoniae, was monitored during the acute phase of infection in its natural host. Bacterial expression profiles of A. pleuropneumoniae isolated from lung lesions of 25 infected pigs were compared in samples taken 6, 12, 24 and 48 hours post infection.

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL11003

75 Samples

Download data: TXT, XYS

(Submitter supplied) Bacteria can use host hormones as environment cue to modulate their pathogenic processes, which was discovered to play essential role in disease development. Actinobacillus pleuropneumoniae is one of the most important porcine respiratory pathogens causing great economic losses in the pig industry worldwide. Stress factors were found to contribute to the outcome of A. pleuropneumoniae infection. To test whether A. more...

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 1 str. 4074

Type:

Expression profiling by array

Platform:

GPL9691

6 Samples

Download data: TXT

(Submitter supplied) LuxS is an enzyme involved in the activated methyl cycle. The by-product of this cycle, autoinducer 2 (AI-2), could be an important quorum sensing signal. LuxS was conserved and regulated many behaviors in different bacteria, but in most species, whether the regulations are related to AI-2 mediated quorum sensing is still unknown. In our previous study, Actinobacillus pleuropneumoniae, the etiologic agent of porcine contagious pleuropneumonia, was found to possess the functional LuxS affecting biofilm formation and virulence. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL9691

32 Samples

Download data: TXT

(Submitter supplied) LuxS is an enzyme involved in the activated methyl cycle and the by-product autoinducer 2 (AI-2) was a quorum sensing signal in some species. In our previous study, the functional LuxS in AI-2 production was verified in the porcine respiratory pathogen Actinobacillus pleuropneumoniae. Enhanced biofilm formation and reduced virulence were observed in the luxS mutant. To comprehensively understand the luxS function, in this study, the transcriptional profiles were compared between the A. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL9691

16 Samples

Download data: TXT

(Submitter supplied) Investigation of whole genome changes in six serotypes of Actinobacillus pleuropneumoniae in control cultures compared to bacteria grown in media containg the iron chelator 2,2'-dipyridyl.

Organism:

Actinobacillus pleuropneumoniae serovar 1 str. 4074; Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 7; Actinobacillus pleuropneumoniae serovar 2 str. 4226; Actinobacillus pleuropneumoniae serovar 6; Actinobacillus pleuropneumoniae serovar 3; Actinobacillus pleuropneumoniae serovar 5

Type:

Expression profiling by array

Platform:

GPL11003

48 Samples

Download data: XYS

(Submitter supplied) To further confirm the genetic diversity and virulence evolution of A. pleuropneumoniae To determine the gene sets with different expression levels (high, normal and low, respectively) Keywords: serotype comparison

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL8394

15 Samples

Download data: TXT

(Submitter supplied) To make clear the genetic diversity and virulence evolution at the genome-wide level of A. pleuropneumoniae Keywords: comparative genomic hybridization

Organism:

Actinobacillus pleuropneumoniae

Type:

Genome variation profiling by genome tiling array

Platform:

GPL7644

14 Samples

Download data: TXT

(Submitter supplied) Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease which causes great economic losses worldwide. Many virulence factors are involved in the pathogenesis, namely capsular polysaccharides, RTX toxins, LPS and many iron acquisition systems. In order to identify genes that are expressed in vivo during a natural infection, we undertook transcript profiling experiments with an A. more...

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Expression profiling by array; Genome variation profiling by array

Platform:

GPL6658

5 Samples

Download data: MEV