Similar studies for GEO DataSets (Select 200006807) - GEO DataSets

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Items: 2

Select item 2000068071.

Genome-wide resources of endoribonucleotide-prepared short interfering RNAs for specific loss-of-function studies

(Submitter supplied) RNA interference (RNAi) has become an important technique for loss-of-gene functionstudies in mammalian cells. To achieve reliable results in an RNAi experiment, efficientand specific silencing triggers are required. Here we present genome-wide data sets forthe production of endoribonuclease-prepared short interfering RNAs (esiRNAs) for human, mouse and rat. We used an algorithm to predict the optimal region for esiRNA synthesis for every protein-coding gene of these three species. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL3991 GPL3992 GPL4372
80 Samples

Download data: TXT

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Accession:: GSE6807

ID:: 200006807

Select item 2000091762.

Genome-scale RNAi profiling of cell division in human tissue culture cells

(Submitter supplied) Cell division is a fundamental process for multicellula organisation. Here we report a genome-scale RNAi screen in HeLa cells designed to identify human genes important for cell division. We utilized a library of endoribonuclease-prepared siRNAs (esiRNAs) for gene-silencing and used DNA content analysis to uncover genes that induced cell cycle arrest or altered ploidy upon knockdown. Rigorous validation and secondary assays were preformed to generate a nine-parameter fingerprint for each of the genes. more...