Similar studies for GEO DataSets (Select 200025615) - GEO DataSets

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Items: 4

Select item 2000256151.

Murine Prostate Tissue: Rb1 null vs. Rb1 E2F binding deficient mutant

(Submitter supplied) Transcriptional profilling of 60 day old prostate tissue from Rb1F/F:Trp53F/F:PB-Cre4 or Rb1R654W/F:Trp53F/F:PB-cre4 mice versus wild type prostate tissue. Profiles used to compare deregulation of known E2F target genes in prostate tissue expressing a mutant Rb1 gene to tissue lacking Rb1 expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
4 Samples

Download data: TXT

Series

Accession:: GSE25615

ID:: 200025615

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000549242.

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene targeted mice

(Submitter supplied) The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of E2Fs. Mice that carry this mutation endogenously (Rb1∆G) are defective in regulating E2F target genes. Surprisingly, cell cycle regulation in Rb1∆G/∆G MEFs strongly resembles that of wild type. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5641
Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE54924

ID:: 200054924

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56413.

Retinoblastoma ∆G/∆G mutant allele effect on quiescent embryonic fibroblasts

Analysis of retinoblastoma (RB) ∆G/∆G mutant MEFs deprived of serum to induce quiescence. The mutant allele disrupts RB protein (pRB) interactions with the transactivation domain of E2F transcription factors. Results provide insight into pRB functions in cell cycle control independent of E2F.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL6246
Series:: GSE54924
9 Samples

Download data: CEL

DataSet

Accession:: GDS5641

ID:: 5641

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000095624.

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis

(Submitter supplied) The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. As p107 and p130 also exert overlapping functions in epidermis, we have generated Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mice to analyze possible functional redundancies between pRb and p130. more...