Similar studies for GEO DataSets (Select 200039842) - GEO DataSets

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Items: 20

Select item 2000398421.

Hypoxia induces myocardial regeneration in zebrafish

(Submitter supplied) Conditional expression of dominant-negative HIF1a in zebrafish cardiomyocytes severely inhibits heart regeneration. To understand more about the mechanism, we performed microarray analysis of wildtype regenerating zebrafish and dnHIF1a regenerating zebrafish to determine which genes are regulated by hypoxia/HIF1a.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
12 Samples

Download data: CEL

Series

Accession:: GSE39842

ID:: 200039842

Select item 2000623892.

In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Rattus norvegicus; Danio rerio

Type:: Non-coding RNA profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL14613 GPL18694
7 Samples

Download data: CEL

Series

Accession:: GSE62389

ID:: 200062389

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000623873.

In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration (RNA-Seq)

(Submitter supplied) Heart failure is a leading cause of mortality and morbidity in the developed world, partly because mammals lack the ability to regenerate heart tissue. Whether this is due to evolutionary loss of regenerative mechanisms present in other organisms or to an inability to activate such mechanisms is currently unclear. Here, we decipher mechanisms underlying heart regeneration in adult zebrafish and show that the molecular regulators of this response are conserved in mammals. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18694
2 Samples

Download data: TXT

Series

Accession:: GSE62387

ID:: 200062387

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000623864.

In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration (array)

Organism:: synthetic construct; Danio rerio

Type:: Non-coding RNA profiling by array

Platform:: GPL14613
5 Samples

Download data: CEL

Series

Accession:: GSE62386

ID:: 200062386

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Select item 2001335715.

Pre-existent adult sox10+ cardiomyocytes contribute to myocardial regeneration in the zebrafish

(Submitter supplied) During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from pre-existing ones. It is unclear whether the heart is comprised of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identified a subset of pre-existent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded massively after cryoinjury. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23274
25 Samples

Download data: TXT

Series

Accession:: GSE133571

ID:: 200133571

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000179936.

Zebrafish heart regeneration

(Submitter supplied) Ischemic cardiopathy is the leading cause of death in the world, for which efficient regenerative therapy is not currently available. In mammals, after a myocardial infarction episode, the damaged myocardium is replaced by scar tissue featuring collagen deposition and tissue remodelling with negligible cardiomyocyte proliferation. Zebrafish, in contrast, display an extensive regenerative capacity as they are able to restore completely lost cardiac tissue after partial ventricular amputation. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Dataset:: GDS3623
Platform:: GPL1319
15 Samples

Download data: CEL

Series

Accession:: GSE17993

ID:: 200017993

Select item 36237.

Heart regeneration in zebrafish

Analysis of hearts of zebrafish 1 to 7 days following partial heart amputation. Unlike mammals, zebrafish hearts display an extensive regenerative capacity. Results provide insight into the molecular basis of this regenerative capacity.

Organism:: Danio rerio

Type:: Expression profiling by array, transformed count, 2 protocol, 5 time sets

Platform:: GPL1319
Series:: GSE17993
15 Samples

Download data: CEL

DataSet

Accession:: GDS3623

ID:: 3623

Select item 2000717558.

Telomerase is essential for zebrafish heart regeneration

(Submitter supplied) Unlike human hearts, zebrafish hearts efficiently regenerate after injury. Regeneration is driven by the strong proliferation response of its cardiomyocytes to injury. In this study, we show that active telomerase is required for cardiomyocyte proliferation and full organ recovery, supporting the potential of telomerase therapy as a means of stimulating cell proliferation upon myocardial infarction.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15583
16 Samples

Download data: TXT

Series

Accession:: GSE71755

ID:: 200071755

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000905959.

Zebrafish heart regeneration

(Submitter supplied) The study compares gene expression profile at 20 days post amputation of the zebrafish ventricular heart between dusp6 mutant and WT siblings.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
4 Samples

Download data: XLSX

Series

Accession:: GSE90595

ID:: 200090595

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013094010.

AP-1 Regulates Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration

(Submitter supplied) The zebrafish has emerged as a powerful model to study cardiac regeneration; however, the mechanisms by which cardiomyocytes respond to damage by disassembling sarcomeres, proliferating, and repopulating the injured area remain unclear. Here, we show that AP-1 transcription factors play an essential role in regulating the cardiomyocyte response. Using ATAC-Seq, we first find that the cardiomyocyte chromatin accessibility landscape is dynamic following cryoinjury, and that AP-1 motifs are the most highly enriched in regions that gain accessibility during regeneration. more...

Organism:: Danio rerio

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20828
14 Samples

Download data: TXT

Series

Accession:: GSE130940

ID:: 200130940

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004891411.

Gene expression arrays of cardiomyocyte ribosome-associated RNAs during zebrafish heart regeneration

(Submitter supplied) A transgenic line cmlc2:TRAP was made to express EGFP-fused ribosomal protein L10a (EGFP-L10a) in zebrafish cardiomyocytes. Then ribosome-associated RNAs were immuoprecipitated from uninjured and injured adult cmlc2:TRAP fish to determine the differential expression changes during zebrafish heart regeneration.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL17210
9 Samples

Download data: PAIR

Series

Accession:: GSE48914

ID:: 200048914

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Select item 20007894512.

Fast revascularization of the injured area is essential to support zebrafish heart regeneration

(Submitter supplied) To better understand the possible mechanisms that vegfaa mutants display to compensate for the lack of vegfaa, we performed transcriptomic profiling of vegfaa+/+ and vegfaa-/- ventricles. Total RNA was isolated from hearts extracted from vegfaa+/+ and vegfaa-/- fish (8 months old) pooling 4 hearts per sample.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL20686
2 Samples

Download data: TXT

Series

Accession:: GSE78945

ID:: 200078945

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Select item 20022415613.

Interplay between calcium cycling and sarcomeres directs cardiomyocyte redifferentiation and maturation during regeneration

(Submitter supplied) Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and redifferentiation to a mature state. We found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. more...

Organism:: Danio rerio; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20828 GPL24676
7 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE224156

ID:: 200224156

PubMed Similar studies

Select item 20007558314.

Single epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration

(Submitter supplied) By contrast with mammals, adult zebrafish have a high capacity to regenerate damaged or lost myocardium through proliferation of spared cardiomyocytes. The epicardial sheet covering the heart is activated by injury and aids muscle regeneration through paracrine effects and as a multipotent cell source, and has received recent attention as a target in cardiac repair strategies. While it is recognized that epicardium is required for muscle regeneration and itself has high regenerative potential, the extent of cellular heterogeneity within epicardial tissue is largely unexplored. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14875
40 Samples

Download data: TXT

Series

Accession:: GSE75583

ID:: 200075583

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006977515.

Early gene expression of regenerating zebrafish hearts following water or atropine treatment

(Submitter supplied) We report global RNA expression profiles from whole zebrafish hearts 24 hours after ventricle amputation. Zebrafish were exposed to atropine or water following surgery.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
2 Samples

Download data: CEL

Series

Accession:: GSE69775

ID:: 200069775

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Select item 20014483116.

Cardiac-tbx20 overexpression enhances heart regeneration by promoting cardiomyocytes dedifferentiation and endocardial activation

(Submitter supplied) The goal of this study is to understand the function of cardiac tbx20 during heart regeneration. By high-throughput sequencing, molecular variations of tbx20-cardiac specific inducing heart in response to heart injury compared with control hearts were demonstrated. We collected the injured heart apex tissue at 7 days post injury and sequenced the transcriptome.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14875
6 Samples

Download data: TXT

Series

Accession:: GSE144831

ID:: 200144831

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Select item 20008162717.

Next Generation Sequencing Facilitates Quantitative Analysis of Tg(hsp70:dn-xBrg1) and wild-type sibling hearts Transcriptomes

(Submitter supplied) The goal of this study is to compare the NGS-derived heart transcriptome profiling (RNA-seq) between Tg(hsp70:dn-xBrg1) and wild-type sibling injured hearts.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
4 Samples

Download data: TXT

Series

Accession:: GSE81627

ID:: 200081627

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014598218.

Single-cell analysis of non-myocytes during heart regeneration reveals sequential coordinated responses from distinct cell populations.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20828 GPL21741
34 Samples

Download data

Series

Accession:: GSE145982

ID:: 200145982

PubMed Full text in PMC Similar studies

Select item 20014598019.

Single-cell analysis of non-myocytes during heart regeneration reveals sequential coordinated responses from distinct cell populations [scRNA-seq]

(Submitter supplied) Cardiac regeneration occurs primarily through proliferation of existing cardiomyocytes, yet the regenerative response also involves complex interactions between distinct cardiac cell types including not only cardiomyocytes, but also non-cardiomyocytes (nonCMs). However, the molecular features and cellular functions of the highly heterogeneous populations of nonCMs and how these populations cooperate to regenerate the injured heart remain largely unexplored. more...