Similar studies for GEO DataSets (Select 200161167) - GEO DataSets

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Items: 20

Select item 2001611671.

Genome-wide maps of the androgen receptor and H3K27 upon MED19 overexpression in LNCaP cells

(Submitter supplied) We report the application of ChIP and RNA sequencing to identify the mechanism whereby stable overexpression of MED19 in androgen-dependent LNCaP cells promotes growth under conditions of androgen deprivation. We determined the MED19 and AR transcriptomes and cistromes in control and MED19 LNCaP cells. We also examined genome-wide H3K27 acetylation in both the absence and presence of androgens. We found that MED19 overexpression selectively alters AR occupancy, H3K27 acetylation, and gene expression. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
60 Samples

Download data: BIGWIG

Series

Accession:: GSE161167

ID:: 200161167

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001612682.

Stable overexpression of MED19 in androgen-dependent LNCaP cells promotes growth under conditions of androgen deprivation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
72 Samples

Download data: BIGWIG

Series

Accession:: GSE161268

ID:: 200161268

PubMed Full text in PMC Similar studies

Select item 2001611703.

Transcriptome profiles of alternative MED19 LNCaP and control LNCaP cells cultured under androgen deprivation with vehicle or R1881

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: TXT, XLS

Series

Accession:: GSE161170

ID:: 200161170

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2002364414.

Transcriptome profiles of canonical MED19 LNCaP and control LNCaP cells cultured under androgen deprivation with vehicle or R1881 treatment

(Submitter supplied) We report the application of RNA sequencing to uncover the process through which sustained overexpression of the canonical MED19 isoform in androgen-dependent LNCaP cells enhances growth under conditions of androgen deprivation. We identified the canonical MED19 transcriptome by comparing control LNCaP cells with those expressing canonical MED19. This research offers significant understanding of the mechanism by which prostate cancer cells grow under low androgen conditions, emphasizing the key role of the canonical MED19 isoform in this process.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
11 Samples

Download data: TXT

Series

Accession:: GSE236441

ID:: 200236441

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000345895.

Elk1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer

(Submitter supplied) Elk1 directs selective gene induction that is a substantial and critical component of growth signaling by AR in PC cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE34589

ID:: 200034589

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000438816.

HIPK2 and MED19 are new regulators of androgen receptor in prostate cancer cells

(Submitter supplied) The androgen receptor (AR) is a mediator of both androgen-dependent and castration- resistant prostate cancers. Identification of cellular factors affecting AR transcriptional activity could in principle yield new targets that reduce AR activity and combat prostate cancer, yet a comprehensive analysis of the genes required for AR-dependent transcriptional activity has not been determined. Using an unbiased genetic approach that takes advantage of the evolutionary conservation of AR signaling, we have conducted a genome-wide RNAi screen in Drosophila cells for genes required for AR transcriptional activity and applied the results to human prostate cancer cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE43881

ID:: 200043881

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000140437.

Genome-wide impact of ART-27 loss on androgen-regulated transcription in prostate cancer cells

(Submitter supplied) The androgen receptor (AR) directs diverse biological processes through interaction with coregulators such as androgen receptor trapped clone-27 (ART-27). The impact of ART-27 on genome-wide transcription was examined. The studies indicate that loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression. Surprisingly, classes of genes that are upregulated upon ART-27 depletion include regulators of DNA damage checkpoint and cell cycle progression, suggesting that ART-27 functions to keep expression levels of these genes low. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
8 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE14043

ID:: 200014043

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Select item 2000139198.

A Novel Androgen Receptor Splice Variant Is Upregulated during Prostate Cancer Progression

(Submitter supplied) The androgen receptor (AR) plays a key role in progression to incurable androgen-ablation resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking the ligand binding domain (designated as AR3, AR4 and AR5) in hormone insensitive PCA cells. AR3, one of the major splice variants expressed in human prostate tissues, is constitutively active and its transcriptional activity is not regulated by androgens or antiandrogens. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
4 Samples

Download data: TXT

Series

Accession:: GSE13919

ID:: 200013919

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Select item 2000717979.

Genome-wide RNA-sequencing (RNA-seq) of benign and malignant prostate cell lines without and with androgen (R1881) stimulation.

(Submitter supplied) RNA-seq data were obtained from hTERT immortalized human prostate transit amplifying EP156T cells (+/- 10 nM R1881 for 48 hrs), progeny tumorigenic EPT3-M1 cells recovered from mouse metastatic tumor (+/- 10 nM R1881 for 48 hrs) and the prostate cancer cell lines LNCaP (+/- 10 nM R1881 for 48 hrs), VCaP (+/- 1 nM R1881 for 24 hrs) and 22Rv1 (+/- 1 nM R1881 for 24 hrs) (obtained from the American Type Culture Collection). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE71797

ID:: 200071797

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Select item 20014840010.

Darolutamide antagonizes androgen signaling by blocking enhancer and super-enhancer activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
219 Samples

Download data: NARROWPEAK

Series

Accession:: GSE148400

ID:: 200148400

PubMed Full text in PMC Similar studies

Select item 20014839711.

Darolutamide antagonizes androgen signaling by blocking enhancer and super-enhancer activation [RNA-seq]

(Submitter supplied) The androgen receptor (AR) antagonist darolutamide has very recently been approved for the treatment of non-metastatic castration resistant prostate cancer (PCa). Here we determined the genome-wide effects of darolutamide on cis-acting regulatory elements involved in androgen signaling with a focus on enhancer and super-enhancer (SE) regions. Darolutamide strongly depleted the AR from regulatory elements and abolished the AR transcriptional signaling. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
112 Samples

Download data: TSV

Series

Accession:: GSE148397

ID:: 200148397

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20014835812.

Darolutamide antagonizes androgen signaling by blocking enhancer and super-enhancer activation [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
107 Samples

Download data: NARROWPEAK

Series

Accession:: GSE148358

ID:: 200148358

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002248313.

Hormone-Independence of Prostate Cancer Cells is Supported by the Androgen Receptor without Binding to Classical Response Elements

(Submitter supplied) Treatment of late passage (LP50) LNCaP cells with R1881 (androgen) and AR shRNA identified a gene program controlled by androgen receptor in the absence of androgen.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4113
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE22483

ID:: 200022483

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 411314.

Late passage LNCaP prostate tumor cells treated with androgen receptor shRNA or androgen R1881

Analysis of late passage (LP50) LNCaP cells treated with AR shRNA or control shRNA, grown in hormone-free media to deplete androgen, and treated with androgen R1881 or vehicle. Results provide insight into molecular mechanisms underlying acquired androgen independence of late passage LNCaP cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL570
Series:: GSE22483
6 Samples

Download data: CEL

DataSet

Accession:: GDS4113

ID:: 4113

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20019591615.

The DNA/RNA helicase DHX9 contributes to the transcriptional program of Androgen Receptor in prostate cancer.

(Submitter supplied) Prostaste cancer (PC) is the most commonly diagnosed male malignancy and an important cause of mortality. Androgen signaling plays a key role in PC pathogenesis and the understanding of the mechanisms involved in the regulation of AR function might pave the ground for the development of more efficacious and long-lasting therapeutic strategies for PC patients. DNA/RNA helicases are emerging as important regulators of many cellular processes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE195916

ID:: 200195916

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013337216.

LincRNA PVT1 associates with EZH2 and with the androgen receptor in LNCaP prostate cancer cells and inhibits the expression of genes involved with cell death, cell differentiation and cell adhesion

(Submitter supplied) Long intergenic non-coding RNA (lincRNA) PVT1 is an oncogene known to be overexpressed in various types of cancer. PVT1 high expression is associated with increased prostate cancer (PCa) risk while androgen-independent PCa progression is correlated with increased androgen receptor (AR) expression. However, the mechanism of PVT1 and AR involvement in the development of prostate cancer is still unclear. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20844
32 Samples

Download data: TXT

Series

Accession:: GSE133372

ID:: 200133372

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022550917.

Total RNA-Seq in control and TRAF4-overexpressing LNCaP cells

(Submitter supplied) We reported the total gene expression in control and TRAF4-overexpressing LNCaP cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
10 Samples

Download data: BIGWIG

Series

Accession:: GSE225509

ID:: 200225509

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015402918.

Total RNA-Seq in TRAF4-overexpressing castration-resistant xenograft tumors and the control castration-responsive tumors

(Submitter supplied) We reported the tumor total gene expression TRAF4-overexpressing castration-resistant xenograft tumors and the control castration-responsive tumors