Similar studies for GEO DataSets (Select 200162273) - GEO DataSets

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Items: 2

Select item 2001622731.

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutic to human β cells

(Submitter supplied) The ability to detect and target β cells in vivo can drastically refine the way diabetes is studied and treated. By an unsupervised Systematic evolution of ligands by exponential enrichment (SELEX) we identified two RNA aptamers that specifically recognize mouse and human β cells in vitro and in vivo. Here we took advantage of commercially available high density protein arrays to identify putative target of the two islet specific aptamers. more...

Organism:: Homo sapiens

Type:: Protein profiling by protein array

Platform:: GPL29450
4 Samples

Download data: GPR

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Accession:: GSE162273

ID:: 200162273

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001972622.

Selection of RNA aptamers against human islets by SELEX and toggle SELEX

(Submitter supplied) Type 1 Diabetes is still an incurable disease characterized by autoimmune destruction of insulin-producing beta cells within the islet of Langerhans in the pancreas. Currently, there are no methods to monitor beta-cell mass in humans or deliver therapeutics specifically to beta cells. Here we performed Cluster Systematic Evolution of Ligands by Exponential Enrichment (SELEX) experiments and toggle SELEX experiments to identify RNA aptamers specific for human islets. more...