Similar studies for GEO DataSets (Select 200197062) - GEO DataSets

Select item 2001970621.

MYCMI-7 - a small MYC-binding compound that inhibits MYC:MAX interaction and tumor growth in a MYC-dependent manner

(Submitter supplied) Deregulated expression of MYC family oncogenes occurs frequently in human cancer and is often associated with aggressive disease and poor prognosis. While MYC is a highly warranted target, it has been considered “undruggable”, and no specific anti-MYC drugs are available in the clinic. We recently identified molecules named MYCMIs that inhibit the interaction between MYC and its essential partner MAX. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: CSV

Series

Accession:: GSE197062

ID:: 200197062

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000473862.

Gene expression study in Neuroblastoma after BET inhibition

(Submitter supplied) We studied transcriptional changes by Illumina HumanHT-12 v4 microarrays in 2 Neuroblastoma cell lines after i-BET-726 treatment

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS5364 GDS5365
Platform:: GPL10558
18 Samples

Download data: TXT

Series

Accession:: GSE47386

ID:: 200047386

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 53653.

BET inhibitor I-BET726 effect on non-MYCN-amplified neuroblastoma cell line SK-N-SH: dose response

Analysis of SK-N-SH neuroblastoma (NB) cells treated with 0.1 or 1 uM I-BET726, a BET inhibitor. MYCN is unamplified in SK-N-SH. BET inhibitors display anti-proliferative activity in MYC driven hematologic cancer models. Results provide insight into the anti-proliferative activity of I-BET726 in NB.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:: GPL10558
Series:: GSE47386
9 Samples

Download data

DataSet

Accession:: GDS5365

ID:: 5365

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 53644.

BET inhibitor I-BET726 effect on MYCN-amplified neuroblastoma cell line CHP-212: dose response

Analysis of CHP-212 neuroblastoma (NB) cells treated with 0.1 or 1 uM I-BET726, a BET inhibitor. MYCN is amplified in CHP-212. BET inhibitors display anti-proliferative activity in MYC driven hematologic cancer models. Results provide insight into the anti-proliferative activity of I-BET726 in NB.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:: GPL10558
Series:: GSE47386
9 Samples

Download data

DataSet

Accession:: GDS5364

ID:: 5364

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001286495.

Differential gene expression analysis of MYCN-amplified neuroblastoma cells after THZ1 and TKI combination therapy.

(Submitter supplied) The CDK7 inhibitor THZ1 has been shown to suppress MYCN gene transcription but not cause significant cell death as a single agent. The tyrosine kinase inhibitors (TKIs) ponatinib and lapatinib were found to exert synergistic anti-cancer effects in combination with the CDK7 inhibitor THZ1, on MYCN amplified neuroblastoma cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
6 Samples

Download data: CEL, XLSX

Series

Accession:: GSE128649

ID:: 200128649

Select item 2001298076.

Gene expression profiling of human neuroblastoma cell line LA1-55n expressing shGFP or shRNA to glycine decarboxylase (GLDC)

(Submitter supplied) Microarray gene expression profiling reveals that silencing GLDC expression downregulates genes required for DNA replication and cell cyle progression

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
6 Samples

Download data: CEL

Series

Accession:: GSE129807

ID:: 200129807

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000735097.

CaSR modulator in neuroblastoma model

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL17400 GPL17692
31 Samples

Download data: CEL

Series

Accession:: GSE73509

ID:: 200073509

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000735068.

CaSR modulator in neuroblastoma model [mouse]

(Submitter supplied) CaSR modulation inhibits neuroblastoma growth

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17400
16 Samples

Download data: CEL

Series

Accession:: GSE73506

ID:: 200073506

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000735049.

CaSR modulator in neuroblastoma model [human]

(Submitter supplied) CaSR modulation inhibits neuroblastoma growth

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17692
15 Samples

Download data: CEL

Series

Accession:: GSE73504

ID:: 200073504

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006272610.

Targeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9052 GPL16043
46 Samples

Download data: BED, CEL

Series

Accession:: GSE62726

ID:: 200062726

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006272511.

Targeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition [ChIP-Seq]

(Submitter supplied) ChIP-seq for Pol II, H3K27ac and H3K4me1 in neuroblastoma

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
18 Samples

Download data: BED

Series

Accession:: GSE62725

ID:: 200062725

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006272412.

Targeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition [Gene Expression]

(Submitter supplied) Global gene expression after CDK7 inhibition by THZ1

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16043
28 Samples

Download data: CEL

Series

Accession:: GSE62724

ID:: 200062724

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022184813.

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression [mouse miRNA-Seq]

(Submitter supplied) Chromosome 17q gain is an independent prognostic marker in neuroblastoma, harboring several potential oncogenes including IGF2BP1 and BIRC5. IGF2BP1 was shown to be upregulated in unfavorable neuroblastoma and correlates with poor patient survival. Here, we report that overexpression of IGF2BP1 in a transgenic mouse model induces neuroblastoma with all characteristics known for human neuroblastoma, including MYCN upregulation and genomic aberrations. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: CSV

Series

Accession:: GSE221848

ID:: 200221848

PubMed Full text in PMC Similar studies

Select item 20018158214.

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247 GPL15456
264 Samples

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Series

Accession:: GSE181582

ID:: 200181582

PubMed Full text in PMC Similar studies

Select item 20018158115.

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression [mouse sWGS]

(Submitter supplied) Chromosome 17q gain is an independent prognostic marker in neuroblastoma, harboring several potential oncogenes including IGF2BP1 and BIRC5. IGF2BP1 was shown to be upregulated in unfavorable neuroblastoma and correlates with poor patient survival. Here, we report that overexpression of IGF2BP1 in a transgenic mouse model induces neuroblastoma with all characteristics known for human neuroblastoma, including MYCN upregulation and genomic aberrations. more...

Organism:: Mus musculus

Type:: Genome variation profiling by high throughput sequencing

Platform:: GPL24247
24 Samples

Download data: CSV

Series

Accession:: GSE181581

ID:: 200181581

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018158016.

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression [mouse RNA-seq]

(Submitter supplied) Chromosome 17q gain is an independent prognostic marker in neuroblastoma, harboring several potential oncogenes including IGF2BP1 and BIRC5. IGF2BP1 was shown to be upregulated in unfavorable neuroblastoma and correlates with poor patient survival. Here, we report that overexpression of IGF2BP1 in a transgenic mouse model induces neuroblastoma with all characteristics known for human neuroblastoma, including MYCN upregulation and genomic aberrations. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
24 Samples

Download data: CSV

Series

Accession:: GSE181580

ID:: 200181580

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018157917.

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression [human sWGS]

(Submitter supplied) Chromosome 17q gain is an independent prognostic marker in neuroblastoma, harboring several potential oncogenes including IGF2BP1 and BIRC5. IGF2BP1 was shown to be upregulated in unfavorable neuroblastoma and correlates with poor patient survival. Here, we report that overexpression of IGF2BP1 in a transgenic mouse model induces neuroblastoma with all characteristics known for human neuroblastoma, including MYCN upregulation and genomic aberrations. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by high throughput sequencing

Platform:: GPL24676
101 Samples

Download data: CSV

Series

Accession:: GSE181579

ID:: 200181579

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018155918.

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression [human RNA-seq]

(Submitter supplied) Chromosome 17q gain is an independent prognostic marker in neuroblastoma, harboring several potential oncogenes including IGF2BP1 and BIRC5. IGF2BP1 was shown to be upregulated in unfavorable neuroblastoma and correlates with poor patient survival. Here, we report that overexpression of IGF2BP1 in a transgenic mouse model induces neuroblastoma with all characteristics known for human neuroblastoma, including MYCN upregulation and genomic aberrations. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15456
97 Samples

Download data: CSV

Series

Accession:: GSE181559

ID:: 200181559

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20012153019.

Direct Targeting of MYCN Gene Amplification by Alkylating Pyrrole-Imidazole Polyamide and CRISPR/Cas9 in Neuroblastoma Cells (CHP-134)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
13 Samples

Download data: TXT

Series

Accession:: GSE121530

ID:: 200121530

Select item 20012152920.

Direct Targeting of MYCN Gene Amplification by CRISPR/Cas9 in Neuroblastoma Cells (CHP-134)

(Submitter supplied) Amplification of MYCN plays a pivotal role in multiple types of tumors and correlates with poor prognosis in high-risk neuroblastoma. Despite recent advances in the treatment of neuroblastoma, no approaches directly target the master oncogene MYCN. Difficulties in targeting the MYCN protein have inspired us to develop a new gene level inhibitory strategy using a sequence-specific gene regulator. Here we generated a MYCN-targeting pyrrole-imidazole (PI) polyamide, MYCN-A3, which directly binds to and alkylates DNA at homing motifs within MYCN transcript. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
8 Samples

Download data: TXT

Series

Accession:: GSE121529

ID:: 200121529

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