GEO DataSets

(Submitter supplied) Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (phase-variable regulons). Phasevarions result from variable expression of cytoplasmic DNA methyltransferases. Variable expression results in genome-wide methylation differences within a bacterial population, leading to altered expression of multiple genes via epigenetic mechanisms. more...

Organism:

Escherichia coli; Actinobacillus pleuropneumoniae

Type:

Other

Platforms:

GPL33074 GPL33073

16 Samples

Download data: RDS

(Submitter supplied) Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae, Neissera Meningtidis and Neisseria Gonorrhoeae, the random switching of the modA gene, associated with a phase variable type III restriction modification (R-M) system, controls expression of a phase-variable regulon of genes (a “phasevarion”), via differential methylation of the genome in the modA ON and OFF states. more...

Organism:

Helicobacter pylori; Helicobacter pylori P12

Type:

Expression profiling by array

Platform:

GPL11628

6 Samples

Download data: TXT

(Submitter supplied) Host-pathogen interactions are of great importance in understanding the pathogenesis of infectious microorganisms. We developed in vitro models to study porcine respiratory tract pathogens using an immortalized epithelial cell line, the St. Jude Porcine Lung (SJPL) cell line. In conditions where cytotoxicity was absent or low, the transcriptomic profile of A. pleuropneumoniae after contact with the porcine lung epithelial cells was determined using DNA microarrays. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL3648

8 Samples

Download data: MEV

(Submitter supplied) The transcriptional profile of the porcine lung pathogen, Actinobacillus pleuropneumoniae, was monitored during the acute phase of infection in its natural host. Bacterial expression profiles of A. pleuropneumoniae isolated from lung lesions of 25 infected pigs were compared in samples taken 6, 12, 24 and 48 hours post infection.

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by array

Platform:

GPL11003

75 Samples

Download data: TXT, XYS

(Submitter supplied) Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is a highly contagious respiratory pathogen that causes severe losses to the swine industry worldwide. Current commercially-available vaccines are of limited value because they do not induce cross-serovar immunity and do not prevent development of the carrier state. Microarray-based comparative genomic hybridizations (M-CGH) were used to estimate whole genomic diversity of representative Actinobacillus pleuropneumoniae strains. more...

Organism:

Actinobacillus pleuropneumoniae; Actinobacillus pleuropneumoniae serovar 5b str. L20

Type:

Genome variation profiling by array

Platform:

GPL6658

74 Samples

Download data: MEV

(Submitter supplied) Microarray-based comparative genomic hybridizations were used to estimate whole genomic diversity of representative Actinobacillus pleuropneumoniae strains. Our goal was to identify conserved genes, especially those predicted to encode outer membrane proteins and lipoproteins because of their potential for the development of more effective vaccines. Keywords: Comparative Genomic Hybridisation

Organism:

Actinobacillus pleuropneumoniae serovar 5b str. L20; Actinobacillus pleuropneumoniae

Type:

Genome variation profiling by array

Platform:

GPL6658

33 Samples

Download data: TXT

(Submitter supplied) Acute pleuropneumonia in swine, caused by Actinobacillus pleuropneumoniae (APP), is characterized by a high and sustained fever. Fever creates an adverse environment for many bacteria leading to reduced bacterial proliferation; however, most pathogenic bacteria can tolerate higher temperatures. CpxAR is a two-component regulation system, ubiquitous among Gram-negative bacteria, which senses and responds to envelope alterations that are mostly associated with protein misfolding in the periplasm. more...

Organism:

Actinobacillus pleuropneumoniae

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30447

6 Samples

Download data: TXT

(Submitter supplied) Nitrate metabolism is an adaptation mechanism used by many bacteria for survival under anaerobic environments. As a by-product of inflammation, nitrate is used by the intestinal bacterial pathogens to enable gut infection. However, the responses of bacterial respiratory pathogens to nitrate are less well understood. Actinobacillus pleuropneumoniae is an important bacterial respiratory pathogen of swine. more...

Organism:

Actinobacillus pleuropneumoniae serovar 1 str. 4074

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32420

18 Samples

Download data: XLSX