GEO DataSets

Analysis of islets from 11-week-old Inhibitor of κB kinase 2/pancreatic and duodenal homeobox 1 transgenics. The IKK2/Pdx-1 model allows activation of proinflammatory IKK2/NF-κB signaling, specific to β-cells. Results provide insight into molecular consequences of NF-κB activation in β-cells.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE47504

14 Samples

Download data: CEL

(Submitter supplied) Canonical IKK/NF-κB signaling is a master regulator of inflammation and innate immunity and has been implicated in the pathogenesis of T1D. To investigate the impact of NF-κB activation on β-cell homeostasis and diabetes development, we generated a transgenic gain-of-function mouse model allowing conditional NF-κB activation via expression of IKK2-CA (constitutively active IKK2 allele) in β-cells using the tetracycline-regulated gene expression system. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4933

Platform:

GPL6246

14 Samples

Download data: CEL

(Submitter supplied) Inflammatory activation of endothelial cells is considered to be the first step in the development of atherosclerosis. Here, we determined the consequences of chronic endothelial NF-κB activation on the development and progression of atherosclerosis as well as plaque regression.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

8 Samples

Download data: TSV, TXT

(Submitter supplied) Analysis of RNAs from VSMCs to find altered pathways in VSMC by CKD

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28330

6 Samples

Download data: XLSX

(Submitter supplied) To understand the difference between CD11c population from the uninfected and MTB HN878 infected mice at transcriptome level.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL21970 GPL20103

14 Samples

Download data: CEL

(Submitter supplied) Human ß cell dedifferentiation as a potent mechanism of diabetes is gaining prominence. Several data suggest an upregulation of the transcription factor SOX9, a progenitor and duct cell marker during ß cell dedifferentiation. However, its targets in such cells need more understanding. Here, we overexpressed SOX9 and a constitutively active mutant (VP16-SOX9∆TAD) in Human pancreatic beta EndoC-ßH1 cells in order to understand its targets.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20103

8 Samples

Download data: CEL

(Submitter supplied) Type 1 diabetes (T1D) is a chronic disease characterized by an autoimmune-mediated destruction of insulin-producing pancreatic β cells. Environmental factors such as viruses play an important role in the onset of T1D and interact with predisposing genes. Recent data suggest that viral infection of human islets leads to a decrease in insulin production rather than β cell death, suggesting loss of β cell identity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL21970

6 Samples

Download data: CEL

(Submitter supplied) Purpose: The Ikk2 maternal-zygotic mutants are the only vertebrates animals completely depleted globally of the Ikk2 function which is expected to block an activity of the canonical NFkB signaling pathway. Transcriptome profiling of embryos before the midblastula transition (MBT) and after MBT may provide a clean strategy to identify the NFkB target genes. Methods: Zebrafish lines were maintained under standard laboratory procedures. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14875

4 Samples

Download data: TXT