Similar studies for GEO DataSets (Select 5800) - GEO DataSets

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Items: 3

Select item 58001.

Interstitial fluid flow effect on noninvasive and invasive ERBB2-positive breast cancer cells

Analysis of non-invasive NeuN cells and invasive NeuT cells (i.e., MCF10A cells overexpressing wild-type ERBB2 or a constitutively active mutant of ERBB2, respectively) treated with IFF. Results provide insight into the molecular pathways activated by IFF in ERBB2-positive breast cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 cell line, 2 protocol sets

Platform:: GPL10558
Series:: GSE64670
12 Samples

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DataSet

Accession:: GDS5800

ID:: 5800

Select item 2000646702.

EMT Alters Interstitial Fluid Flow-induced Signaling in ERBB2-positive Breast Cancer

(Submitter supplied) A variety of mechanotransduction forces are altered in the tumor microenvironment (TME) and these biophysical forces can influence cancer progression. One such force is interstitial fluid flow (IFF) - the movement of fluid through the tissue matrix. IFF was previously shown to induce invasion of cancer cells, but the activated signaling cascades remain poorly understood. Here, it is demonstrated that IFF induces invasion of ERBB2/HER2 expressing breast cancer cells via activation of phosphoinositide-3-kinase (PI3K). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5800
Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE64670

ID:: 200064670

Select item 2000523083.

Expression data from H358

(Submitter supplied) Tumors that show evidence of epithelial to mesenchymal transition (EMT) have been associated with metastasis, drug resistance, and poor prognosis. EMT may alter the molecular requirements for growth and survival in different contexts, but the underlying mechanisms remain incomplete. Given the heterogeneity along the EMT spectrum between and within tumors it is important to define the requirements for growth and survival in cells with an epithelial or mesenchymal phenotype to maximize therapeutic efficacy. more...